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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Vaccination and Dog Cancer

Updated: April 13th, 2021

Vaccinations & Dog Cancer

Are vaccinations and dog cancer linked?

A reader recently posed a question about vaccinations and links with cancer in dogs.

I discussed this in more detail in the Guide, along with many other factors that may (or may not) have links to cancer.  But, since it came up, I thought it might make a good post.

If reader is looking for a vilification of vaccines, a carte-blanche condemnation of the practice of vaccination, a hysterical, reactive, anti-ist, myopic tirade against vaccines in general, you may want to stop reading.  This is not the proper forum for that type of thing so common in certain circles these days.

Okay, with that out of the way, let’s look at the situation like rationale, clear thinking human beings.  The situation is not clear cut, and that recognition should be established early.

For those who want the bottom line now: No vaccinations for dogs with cancer. None. Vaccinations have complex interactions with the immune system and these are not predictable and can be harmful in dogs with cancer.  Use the minimum vaccinations for your pet’s lifestyle, needs, and other health issues.

But don’t eliminate all vaccinations in healthy pets. From the viewpoint of someone who deals with diseases that vaccines prevent, I can promise you that if your dog were to experience parvo or distemper, you would wish she had been protected…but only after the fact, after you had endured the pain of witnessing the horror show of these problems in your loved dog.

And of course vaccinations have side effects, like anything (yes, even homeopathy), and these must be contended with.

Like any medical intervention, we have to analyze whether the costs outweigh the benefits.  With vaccination, I’ve stated the benefit already: prevention of diseases that your dog may contract if they are present. This means, of course, that if there is no Lyme disease where your dog walks, no ticks to spread the bacteria, don’t vaccinate against Lyme disease. I give very little kennel cough vaccine to adult dogs because there is very little kennel cough where I practice. I don’t vaccinate my patients against rabies as we have a rabies-free state. I don’t vaccinate against leptospirosis in any puppy, Dachschund, Poodle, or dogs that are not always going in fresh water, where it is carried.

Yet, we have parvo outbreaks. And friends, parvo can kill a dog just like cancer. I quote clients about a 70-80% survival rate with 24-hour intensive care but we treat the disease very aggressively and use many different tools to do so.  I suspect overall survival rates for parvo are lower than that. And friends, if your dog’s intestine is bleeding out and he is lying on the ground with low blood sugar, destroyed electrolytes, and vomiting but can barely lift his head to do so..suddenly…preventing parvo doesn’t seem like such a bad idea after all.

But what about the negatives of vaccination?  Well, these are not quite as well documented in the conventional literature. This means that you cannot find all that much on direct links between vaccines and diseases or problems resulting from them in the dog. However, there are some pretty compelling bits of information from human medicine that we can apply to dogs.  This is especially true as dogs are models for human cancers, and we vets use many of the same tests, drugs, and other treatments that are provide to humans.

Alternative vets describe something called vaccinosis, which means the vaccine negatives, more or less. An “-osis”, similar to a disease.  These effects could include, for example, allergic reactions. (Then again apples make my lips swell and I still think apples are okay for other people…but I digress..) So a vaccination can cause an allergic reaction, but they are pretty rare, and can most often be managed in a strait-forward way.

Vaccines are now being more or less accepted as increasing the risk for immune system problems, especially involving the blood.  These problems include cases where the immune system starts to attack blood cells, like red or white blood cells, or platelets. For this reason, in dogs that already have a predisposition towards those diseases (Poodles for example, or dogs with clinical inflammatory disorders of any kind), I don’t vaccinate or do so much less, or with precautionary steps.

In cats, there is actually a tumor specifically caused by vaccinations, called a vaccine-induced sarcoma, or “vaccosarcoma”. This is not found though in dogs.

Now comes the murkier stuff that is not very well documented, but is suspicious and raises flags in my mind. First, the immune system has traditionally been thought of as if it had unlimited ability to to respond to things. In reality it does not. Vaccination of newborn babies creates what is called a polarity shift in the immune response. This means the immune system shifts to defend itself against the diseases in the vaccine, as a response to the vaccination. Here is a publication in humans, and here is one in mice, and here’s a related one in mice as well.

This polarity shift pulls the immune system away from cancer surveillance later in life (shown in rodents anyway), and appears to be a permanent change.  In other words, the immune system is  primed to fight infectious disease, but at the expense of protecting or screening the body from developing cancer cells.

Now, this has not been shown in dogs, but it has been in other species. And I strongly suspect that the same effects occur in dogs.  And who knows what other items we don’t know about. Who knows about the heavy metals or preservatives and whatnot in vaccines, whether in dogs there really is a connection to other forms of immune mediated disease (I suspect so), or certain neurologic or other problems.

In my practice therefore, I start the vaccine series a little later than normal to try to minimize this possible polarity shift. I cannot prove it works, but because there is compelling evidence of this phenomenon, I do what I can to include these ideas in daily medicine. We also only vaccinate with core vaccines at 1 and 4 years, then only possibly later if needed.  We test for protection using what is called a titer test, which is a crude way of assessing protection in a dog at a point in time….to see if a vaccination is needed, before just administering it.  We try to minimize other vaccines as much as possible.  When the dog does not get the vaccine, they get a titer test to make sure they have left over protection from previous vaccinations.

Some guardians like to give Thuja occidentalis, a homeopathic that seems to help a little with “vaccinosis”.  I kind of like Thuja. Data? Nope.

So, those are some of my thoughts concerning vaccinations in dogs. I hope this helped clarify this rather complicated issue.

For more information about topics like this and their connection to cancer, read the Guide.


Dr D

Leave a Comment

  1. phoebe luo on February 8, 2018 at 11:14 am

    Hi Dr. D,

    My name is Phoebe and I’m a neuroscience translator in Beijing. I’m sure you hear this really often, but HUGE fan of your book! My 17 year-old chihuahua has been diagnosed with spindle tumor/mast cell tumor and I’ve been warned by a few friends to not vaccinate her, and from your article I have confirmed this. I have adopted 9 older rescue dogs and I am not sure if I should vaccinate them? They are all above age 10. I have a question about neoplascene treatment for my chihuahua– she is at the first stage and it’s at one single spot on her front left limb. The vet care in China is not very advanced and I’m not sure if I can go with the vet’s recommendation, which is to have her amputated and go through chemo. I feel like it’s premature because she is only at stage 1 and maybe neoplascene would be a better way to go about this. Is there anyway I can reach you or your practice for an email or phone/video consultation? Rescueing dogs is my passion (I have a community for rescue dogs in Beijing) and we would really love to have an expert’s advice in the future because of the lack of professional help here.


    • Amber Drake on February 8, 2018 at 11:44 am

      Phoebe, please contact us at, and we’d be happy to send you the information Dr. Dressler has provided us with for a consult.

      • phoebe luo on February 8, 2018 at 12:49 pm

        thank you! I’ve sent u an email~

  2. Artiewhitefox on January 23, 2016 at 2:16 pm

    People are learning that vaccinations are not good for Humans. People are naïeve enough to think vaccinations are not bad for non human animals? Those shots don’t think I will be good to one not being bad to another. Shots need to become extinct.

  3. […] has been growing in recent years and the rate of cancer has as well. Demian Dressler, DVM, wrote this article for the Dog Cancer Blog that explains how detrimental vaccines can be to dogs who currently have […]

  4. KH on July 10, 2014 at 4:05 am

    Thank you, Dr D. I am thinking it was my post, about Jackson, that spurned this post. Thank you.

  5. Vaccinations and Cancer | Dog FYI: Dog Health Information Library on April 24, 2014 at 7:11 pm

    […] Full article Dog Cancer Blog: Vaccination and Dog Cancer […]

  6. […] As the Dog Cancer Vet Dr. Dressler stated in his blog post “Vaccination and Dog Cancer,” […]

  7. Vicki on May 21, 2013 at 2:55 pm

    I don’t really agree with giving dogs more than they need. I feel they should be vacinated in there puupy years, but not so much after than. I just had to put my Lab/Shepherd mix down because he had cancer. I was good at getting him his yearly shots, now I don’t think they need it. You can get a blood test to see if they still have the vaccine in them. I have a friend who has the blood tests done on her Labs and they had to much of the vaccine still in them. You know when I was growing up you never heard of people taking their dogs to the vet and they lived a long and healthy life. If I get another dog I will not have all the vaccines they say that you ahould have.

  8. Nancy on May 6, 2013 at 12:57 am

    Our precious lab mix was diagnosed with fibroblastic sarcoma – intermediate stage – last April after biopsy of a lump the size of my fist that ballooned within a week on his abdomen.

    Today, he is in remission, thankfully. Our vet vaccinated him in February with a 3-year rabies shot and what she said was his “last” distemper/parvo etc. shot. She knew full well of his cancer, yet she vaccinated him anyway. He is almost 9. Now he is having full blown nail/hoove trouble, thanks to the vet tech cutting his nails so short. So we have to deal with the e-collar for weeks and 3 of his 4 feet are suffering. He’s been on antibiotics for a month, and ironically…we may have to have him put down, not due to the cancer, but due to his nails.

    Needless to say, I “fired” the vet. Chemo & radiation are not an option for us due to costs. We have opted for palliative care when the time comes. I’ll have to find another vet in the meantime. Thank you for your info, it does help some.

  9. Kyra Walter on May 5, 2013 at 6:21 am

    My 11 yr old pom diagnosed with TCC of bladder four months ago couldn’t take Piroxicam because it made her bleed, so homeopathic doctor recommended Terebinthina 30 c three pills per day…also she has calcium deposits in her eye and it caused ulceration..she recommended Euphrasia 30c twice daily three pills…she says they have no side effects…do they??? thank you

  10. Mark on May 1, 2013 at 3:25 am

    At Kelsey,

    Just don’t give them the shot… that’s what I do. A law says you have to have it done? Yet, evidence seems to support it will protect 5-7 yrs, maybe life…

    I can’t say for sure, but I know my Dane was doing quite well, never had shot since a pup, when she was 8 yrs old, I finally decided maybe I should get the rabies one again, 6 weeks later she had lymphoma… any connection, dunno, but how many times does this happen and nothing is reported?

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