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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Food and Nutrition for Dogs with Mast Cell Tumors

Updated: August 24th, 2023

Summary

Dr. Dressler’s Dog Cancer Diet is appropriate for most dogs, but dogs with mast cell tumors need a few modifications. Read this if your dog needs a low-histamine diet.

We know that good nutrition is the foundation of health. The Dog Cancer Survival Guide devotes an entire chapter to a real food diet for our dogs battling cancer, advising both on the foods to give, and those to avoid.

Dogs with Mast Cell Tumors MAY Need a Low-Histamine Diet

While every cancer journey is a tough one, the diagnosis of Mast Cell Tumor (MCT) presents a bigger challenge when it comes to feeding.

In some (not all!) mast cell cancers, large amounts of histamine are released in the body, causing irritation and itching. In addition to itchies on the skin, the irritation can also be found in the gut.

That can cause nausea, vomiting, and diarrhea.

Antihistamines May Help (and Are Often Prescribed)

Most MCT treatment protocols include an antihistamine to help block histamine receptors.

So why look at diet, if you are giving an antihistamine?

Well, some foods have high histamine levels that can irritate the tummy tissues. Others may trigger the release of histamines in the body.

If your dog is itchy and/or having GI issues, making some of the modifications listed below might help.

The Dog Cancer Diet Is Fantastic for Mast Cell Tumors … With a Few Modifications

Even some of the healthiest, highest recommended foods Dr. Dressler recommends in his diet may not be appropriate for a dog with MCT.

If your dog is itchy and scratchy, Dr. Dressler’s post on Diets for Dogs with Mast Cell Tumors addresses this cause and effect in more depth.

Dr. Dressler has also provided insights for and reviewed this article, as well. The guidelines below will help you to modify his diet for your dog.

But first, let’s review when histamine is a problem … and when it is not.

 

Histamine … Is It a Problem for Your Dog?

First, it’s important to know that just because your dog has MCT doesn’t mean your dog is automatically having a problem with histamine levels.

Not all dogs with MCT have histamine problems!

Histamine is an important part of the body’s normal functioning. It’s made in several ways. It doesn’t just come from the diet.

That’s important to keep in mind. Changing the diet won’t necessarily eliminate histamine. It will just keep you from adding MORE histamine.

Put another way, if you have a sunburn, you don’t go out in the sun and try to get a tan, right? You avoid the sun until your burn has healed.

Same thing here. If your dog is in histamine overload, you avoid high histamine foods until those levels go down.

Signs Your Dog Is In Histamine Overload

So how do you know if your dog is in histamine overload, and you should change the diet?

If your dog is currently vomiting, itching, feeling sick, having reduced appetite, or swelling (welts) … histamine is probably in overload.

Signs Your Dog Is NOT In Histamine Overload

If your dog seems calm, isn’t itchy and scratchy, is eating and eliminating normally, has normal skin tone, and is basically acting fine … she is likely not in histamine overload.

Also, if there are no or few Mast Cell Tumors … for example if you’ve surgically removed them all … he’s almost certainly not in histamine overload.

Reducing dietary histamine is not necessary if your dog is not in histamine overload.

Why? Well, MOST of the ingredients in Dr. Dressler’s dog cancer diet are already on the low-histamine list. It’s already a pretty low-histamine diet as it is …

… and there are only a couple of ingredients that are high in histamine. And those are important sources of some vitamins and minerals … so if you don’t have to eliminate them, it’s way easier.

Balancing Act: Mast Cell Tumor Dogs May Go In and Out of Histamine Overload

In a way, histamine manages water flow in the body. When it is released, the area will swell, bringing immune activity.

For example, histamine is one of the things that causes a bug bite to swell up. It’s helping to heal. When it’s no longer needed, the body stops manufacturing it. The tissues stop swelling.

Mast cells that have tumors in them do not always manufacture and release more histamine. Sometimes, they don’t do that at all.

Sometimes they do, but then the antihistamine you give helps them to stop.

So this is not an all or nothing situation. You may not have to deal with histamine overload at all. Or you may have to deal with it for a couple weeks, and then stop.

How to Decide Whether to Use a Low Histamine Diet for Dogs with Mast Cell Tumors

So … it’s pretty simple.

If your dog has high histamine symptoms, reduce histamine in food. Again, you won’t be treating the problem … you just won’t be adding more histamine unnecessarily.

If your dog stops having symptoms (or if your dog never has any symptoms), you can resume a normal dog cancer diet. Again, dietary histamine is not likely going to trigger a problem if one doesn’t already exist.

The histamine problems in mast cell tumor dogs are coming from the cancer, not from the diet … reducing histamine in the diet is about reducing unnecessary excess, not about treating the cancer.

So you may only need to modify your dog’s diet for a little while. Once symptoms stop, and your dog is feeling better for a few days or a week, try adding one item back in and see how she does. If she tolerates it, you can continue feeding those few higher-histamine items.

If you see itching, or tummy upset start up again, you can remove those higher-histamine items again.

Rarely, a dog needs to have a low-histamine diet on a regular basis. In those cases, you’ll see itching and other symptoms start up as soon as you stop a low-histamine diet. In those cases, you want to keep a low-histamine diet for as long as necessary to keep your dog comfortable.

Like most things, this is all about balance and is not a yes/no/black/white topic.

The bottom line: Follow the symptoms, and feed accordingly.

Low Histamine Dietary Guidelines for Dogs with Mast Cell Tumors

It’s surprising just how tough it has been to find more thorough information on what foods to give a dog with MCT.

I honestly don’t know whether this is because no one wants to publish a recommended list, or no one has thought of it yet. But I know the need is there because our readers are asking for it.

Must-Understand Concepts for a Low Histamine Dog Cancer Diet

With Dr. Dressler’s expert input and my own background with animal nutrition, I’m going to give you a list of foods to avoid (and to choose).

As long as you promise to note the following:

  • Follow the recommended proportions/amounts in Dr. Dressler’s diet. Don’t go overboard on any ingredient in the yes list below. Five pounds of Brussels sprouts at a time is not good … even though they are on the “ok” list.
  • This list comes from human-food resources. The lists below were compiled by researching several human-food resources for histamine-restricted diets. Then, we screened those lists against the highest recommended foods for dogs with cancer. Why? Because dogs and humans share many similarities physiologically, and dogs are the preferred test subjects for human cancer research. What helps us in our diet usually helps them in their diet when it comes to cancer. Some of these sources are The Histamine and Tyramine Restricted Diet, and The Histamine Restricted Diet.
  • No list will ever be perfect or apply to every dog. This list contains foods that are generally safe and liked by dogs in general. That said, YOUR dog may not like some of these foods. Your dog may not be able to digest some of them well. Every dog is different, and what works for most may not work for your dog, and vice versa.
  • You will find conflicting information online. It would be great if every article you read agreed with every post, comment, or tweet. And it would be really great if every thing you read online agreed with what your veterinarian recommends. Well, that’s not real life. As you research histamine and mast cell tumors, you may find a list that recommends against one or more of the items below. You may find lists that contain other foods. You can find anything on the internet if you try hard enough. We researched low-histamine foods and high-histamine foods and then screened them against the dog cancer diet. These lists are not like other lists.
  • Don’t drive yourself (and your dog) crazy about histamine. Remember that it’s nearly impossible to eliminate everything that may trigger histamine. What we are trying to do here is reduce histamine load by not adding it via the diet. This is better than ignoring the problem, but it’s not addressing every histamine problem. Give yourself a break if your dog is still uncomfortable even if you change the food. Mast cell tumors are not fun.


The Definite ‘No’ List: High Histamine Foods to Avoid

Here is a list of foods or ingredients that should be completely avoided if possible if your dog is in histamine overload. A few of these are included in Dr. Dressler’s dog cancer diet, so I have listed modifications below. Otherwise, avoid:

All Fermented Foods
All Processed Foods
All Leftovers
All Fish**
All Berries***
All Stone Fruits (ex: Apricots)
All Cheese
Citrus Fruits
Yogurt
Tomatoes
Soy
Apples
Quorn
Quinoa
Yeast products like Bread
Cottage Cheese*
Eggs
Walnuts and Pecans
Processed Oils with BHA/BHT
Anything Pickled
Anything with Vinegar

*Cottage cheese is included in Dr. Dressler’s dog cancer diet for its food-based calcium content. And, because dogs love it. If you are avoiding cottage cheese to reduce histamine, make sure you give chicken or turkey necks as outlined in the diet … or give a calcium supplement, or ground-up and boiled eggshells.

**Fish is on the list of proteins you could give in Dr. Dressler’s diet, and he also recommends giving sardines as treats. While your dog is avoiding histamine, do not use fish as your protein, and avoid sardines. (Sorry, puppy, I know they are delicious.)

***Berries that are dark and deeply colored, like raspberries, blueberries, and blackberries, are included in the diet as “optional healthy toppings.” While your dog is in histamine overload, don’t add them.

The Recommended ‘Yes’ List: Low Histamine Foods to Include

I hope you’ll be pleasantly surprised with this list. Most of these foods are already included in the dog cancer diet!

When you are reducing histamine, focus on using the following low-histamine foods:

Chicken Breasts
Lean Beef (trim off any fat)
Turkey Breasts
Chicken or Turkey Necks
Liver
Mung Beans
Organic, Rolled Oats (not instant)
Brown Rice (not instant)
Cooked Cabbage
Broccoli
Brussels Sprouts
Butternut Squash
Cauliflower
Red and Yellow Bell Peppers
Pure Peanut Butter
Fresh Garlic Cloves (in small amounts of course)
Fresh Ginger
Coconut Oil
Krill Oil/Extra Virgin Olive Oil
Flaxseed/Linseed Oil

Now, if you look at that list, you will see about 90% of the foods listed in the dog cancer diet there. So, see? Most of the diet is good for cancer AND low in histamine.

As always, the better quality, organic meats are always better to serve, if possible. And please check out the cooking guidelines below as well.

 

Low Histamine Commercial Dog Food … ???

Unfortunately, even among the best-quality commercial dog foods, we have yet to find one that matches these recommendations.

So if your dog is showing symptoms of histamine overload, cooking for him or her is your best bet.

However, there are some really great foods available these days for when your dog is no longer in histamine overload. We have listed many in the Dog Cancer Shop and Dog Cancer Shop UK.

If a commercial food ever does come on the market that is of high quality and would be appropriate for dogs with histamine overload, we’ll update this article.

Special Cooking Considerations for a Low Histamine Diet

There are a couple of things to keep in mind as you cook for your dog. Histamines can be generated by the cooking process, for example.

Use Low Temperatures, and Don’t OverCook!

Histamine levels rise as meat cooks. And they continue to rise after meat is removed from the heat.

So, always cook your meat at low temperatures (below 300 degrees Fahrenheit).

And don’t overcook your meat.

For example, I’ve found the best way to cook chicken and turkey is to simmer the breasts in a large pot of water.

You get more meat for your money and you have a great broth too. Note: bone broth is high in histamines, but meat broth is not.

Freeze Meat, Don’t Refrigerate It

Histamines can continue to develop in the refrigerator, so refrigerating your cooked meat is not as good as freezing it. (Refrigerating cooked vegetables and grains is less troublesome.)

I freeze cooked meat immediately in meal-sized portions.

And don’t throw out that broth — it can be frozen in ice cube trays for treats. Or, you could use small containers that yield frozen brothcicles to melt down later for your dog’s delight. Freeze in containers up to a cup in size.

No Leftovers for a Low Histamine Diet

Leftovers are on the “no” list above, but it’s worth discussing this a little.

Many of us cook the dog cancer diet in a big batch and refrigerate it for a few days.

But if your dog has mast cell tumors, and you need a low-histamine diet, you might consider freezing every day’s portion individually.

That’s because histamines rise in food as they sit in the fridge.

Leftovers have higher histamines than fresh cooked foods. When you freeze the fresh-cooked food, you avoid excess histamine accumulation.

Again, vegetable and grain leftovers also develop histamines as they sit. But they do it more slowly than meat.

It really depends upon your own kitchen habits, but it may be most convenient to cook a big batch of food and then freeze it in portions. That way you know you are avoiding excess histamines that might develop in the fridge.

Are Fish & Krill Oil Supplements Safe for a Low Histamine Dog Cancer Diet?

If fish is high in histamines, is there cause for concern if you give your dog a fish oil supplement?

Possibly … although the processing of the fish to get its oil alters the original material, and likely removes any problematic metabolites that cause histamine reactions.

If you want to be very safe and make a conservative choice, avoid fish oil if your dog is in histamine overload.

What about krill oil?

In general, Dr. Dressler recommends krill oil over fish oil supplements for many reasons which he explains in the book. We have found that Mercola Krill Oil and Jarrow Formula Krill Oil report that any histamine is “below detectable levels” which is about as good as it can get.

Generally, the benefits of giving a high-quality krill oil for its anti-cancer properties outweigh the infinitesimal amount of histamine which may be present.

Krill oil (and fish oil) are important supplements in full spectrum cancer care. Giving krill oil, especially, is almost certainly better than avoiding it for the infintesimal level of histamines it may contain.

Both of these oils are available through the Dog Cancer Shop.

 

A Labor of Love for Your Dog with Mast Cell Tumors

All of this sounds like a lot of work, I know. But once you’re in the swing you can actually make your doggie food preparation a lot of fun.

When you have your ingredients, a little organization and an hour of time are all you need to prepare a week of food for your dog.

While your meat is cooking you can prepare a pot of organic, rolled oats or brown rice, and lightly cook the vegetables.

Store the meat portions in one container, oat/rice in another, and the various vegetables in a third.

Freeze the meat, refrigerate the others.

When food time nears you can select from each to make a delicious meal. Either thaw to room temperature if you have the time or warm in a microwave. Remember not to overheat.

I’ll bet your dog will be gazing wide-eyed until you put that bowl down.

I hope this helps those of you out there who were shaking your head in frustration. Take a deep breath, sit down with your dog and make that shopping list. You’re doing great!

Happy Tails!

Susan


Leave a Comment





  1. ted tone on April 1, 2021 at 5:13 pm

    We are a patient of Dr D, but this lists of foods is not accurate. Please review and replace.
    Thank you.

    • Molly Jacobson on April 2, 2021 at 11:46 am

      Thanks for your comment, Ted. Can you please be more specific?

  2. Kacey on January 27, 2021 at 8:15 am

    Hi, I saw that garlic is on the OK list of food, but I thought garlic was bad for dogs?

  3. Karen Pomer on January 21, 2021 at 2:46 pm

    My dog no longer has MCT, but she’s been on the above low-histamine diet since she was diagnosed in April. Since then she’s had surgery and chemo. And she is currently in remission (paws-crossed.) She loves the food on this diet including Krill oil! Is there any reason that I should take her off it?

    • Molly Jacobson on January 22, 2021 at 9:30 am

      Hi Karen! Many folks and many dogs do really well on a low-histamine diet for a long time. It’s still nutritionally sound… so there’s no reason to take her off it if she’s doing well. We generally assume that even if a dog is in remission, cancer could still recur — so I personally stay with things that are working to maintain!

  4. Elizabeth on December 16, 2020 at 6:51 am

    My dog just had extensive surgery to remove mast cells. The majority of them were at #1; one was more severe but the surgeon said she got the margins.;After bringing her home, I found another small mass that was either overlooked or had sprung up overnight. I took her to my local vet and she suggested it might be too soon to put her under anesthesia again due to her heart mumur. i have begun a regiment of Benadryl which has shrunk the tumour. I’m wondering how long I should have her on the Benadryl and if the Benadryl will cause the tumour to eventually go away?

    • Molly Jacobson on December 17, 2020 at 9:57 am

      Hi Elizabeth, mast cells release histamines, so tumors in mast cells can cause them to release EXTRA histamine. That results in swelling (histamine is what causes swelling and hives, welts, during allergies). Anti-histamine meds like Benadryl reduce the histamine, so they also reduce the swelling. That’s why Benadryl is often used in mast cell tumors — it relieves the uncomfortable symptoms of excess histamines. Benadryl doesn’t actually kill mast cell tumors — it does reduce the symptoms, though. As far as I understand Benadryl is safe to use over the long term, but you should definitely check with your veterinarian. Make sure you have lots of water available for your dog, because they can cause dehydration!

  5. Alfie’s mom on September 29, 2020 at 7:16 pm

    Hi Susan, thank you for the tips. I have a question about meat – you mentioned that cooking meat raises histamine levels and yet there is a mention of a raw meat diet. Is raw meat not appropriate for dogs with MCT? My pup has been on raw (farm-raised) meat/organs diet (with steamed org veggies) for several years and unfortunately he still developed an MCT. Should I start cooking his meat?

    • Molly Jacobson on June 28, 2021 at 2:52 pm

      Hi — in general, Dr. Dressler does not recommend feeding a dog with cancer a raw diet. He likes raw diets for healthy dogs, but once a dog has cancer, their immune system is by definition compromised. If there is a whiff of bacteria or contamination in the raw food, veg or meat, they will be less likely able to fend it off. And the immune system will be fighting it with energy that otherwise would go to the cancer battle! So … in general, yes, cooking meats is a good idea. If it’s ground meat, it should be cooked all the way through. If it’s whole meat, lightly cooking the outside so the exposed surface is cooked is a good idea. You can still leave the meat “rare” inside!

  6. Georgeann Erskine on September 19, 2020 at 8:05 am

    +I have a 9 1/2 year old Red Bloodhound female who has a large Mast Cell Tumor on her front leg at the joint to her chest. She is under the care of a well know Oncologist in Northern California. I felt I was careful with her food, as I only give her Taste of the Wild Salmon kibble along with fresh chicken broth, and fresh chicken breast, some tumeric in yoghurt and a wild caught fish oil gell cap vitamin every day. She is currently on Clavamox bc she has a slight urinary infection.

    She is on Palladia, Prednisone, Benedril, and Prilosec for the Tumor. It seems that she is highly sensitive to the prednisone, so we are continually monitoring differnt dosages due to her panting episodes.

    She sees the oncologist about once every 4-6 weeks for blood work, chest x-ray and general consultation and examination.

    After reading this article, I may be doing the wrong diet for her. Can you give me any insight into that? Or any other comments or suggestions you may have about any of this information.

    I would greatly appreciate it. Let me know if you need additional information. I will do anything for my sweet girl to either make her life more comfortable or provide her with any additional medical support to help you in her last years with me. She is an amazing girl!

    Thank you so much.

    Georgeann

    • Molly Jacobson on September 21, 2020 at 10:21 am

      Hi Georgeann! The list of “no” and “yes” foods in this article are the guidelines to follow if your girl is actively itchy. Some folks like to use these as guidelines for diet with mast cell tumor dogs even if they AREN’T currently itchy and in histamine overload. However, since histamine comes from many places (and most often, the tumors themselves) you can’t reduce histamines by diet alone. You might try cutting out the “no foods” for a while and see how she does — that’s really the best way to know for sure. There is no “one right diet” for every dog, just like there isn’t for every human. You just need to try things and see how she does. Best of luck in caring for your lovely girl!

  7. Jennifer on June 9, 2020 at 4:28 am

    Hi there! Does anyone know if the product DGP (Dog Gone Pain) is safe for a dog with a MCT?
    My lab is 13.5 yrs old and though he’s still spry and lively, I’ve noticed him slowing down in the last little while. I want to make sure that we’re keeping his muscles and joints comfortable and I know DGP has worked miracles for so many pups, especially senior pups.
    Are there any ingredients in DGP that are on the “No” list for mast cell tumours? I certainly do not want to aggravate the one he has. Thanks very much in advance!

  8. DG on May 18, 2020 at 2:22 am

    Why would you have raw garlic on this list! It’s poison to dogs!!!

    • Molly Jacobson on May 19, 2020 at 12:36 pm

      Aloha DG, that is not true, garlic is not poisonous to dogs. Garlic is very good for dogs in the small amounts recommended by Dr. Dressler in the dog cancer diet. What is bad for dogs is garlic eaten in the amounts they were forced to consume in the study that tested its safety: a clove per pound at each meal. Can you imagine the suffering of the dogs who were forced to eat that much? No one would ever do that in real life. A teaspoon of garlic is about half a clove — that’s what is recommended by Dr. Dressler. Here’s an article that explains more: https://www.dogcancerblog.com/articles/full-spectrum-cancer-care/dog-cancer-diet/isnt-garlic-bad-dogs/

  9. John N. Bihm on February 19, 2020 at 5:50 am

    Hi,
    I recently picked up the Dog Cancer Survival Guide and it is helping my pup battle his mast cell cancer. I am following the cancer mast cell diet and he loves it tremendously!!! I would like to make homemade treats for him because the store-bought ones aren’t healthy for him. I plan on using mothers oats and a little bit of fresh natural peanut butter. I do not want to use flower. What would you recommend as a binder to keep everything together?
    Also, he will be starting his APOCAPS this weekend.
    Thank you from me and Milo who is a 90 pound bulloxer.

  10. Lauren on December 4, 2019 at 8:14 am

    Hello. My 12 year old dog Roxie was diagnosed with Mast Cell Tumors on her left hind leg in June 2019. She has been on prednisone, Benadryl and has even had surgery. The tumors have since gotten worst. Roxie is still very alert and in good spirits. I am determined that she will survive this. Today I decided that I would look into natural healing remedies, changing her diet etc. and that is when I found your website. I have been reading and researching a lot about this disease and your website has been helpful to me. Today will be the start of Roxie’s new diet along with other things as far as meds etc. Thank you!

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