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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Diet for Dogs With Mast Cell Tumors

Updated: December 6th, 2019

Friends,

Today’s post will likely be met with some skepticism from those immersed (and confined) to our Western medical approach.  So if this is your framework, please keep an open mind.  You will be pleased to know that the information here is taken from little known, but still Western, data banks.

I have recently been looking into some ways of decreasing some of the horrible effects of severe mast cell tumors in dogs.  Lots of talk these days about Palladia, but there is more you can do!

As many of you are well aware, these cancers are able to release, on an intermittent basis, large amounts of chemical signals that produce nasty effects on the body.  There are many different ones, and to avoid being utterly dull, here are just a few:  histamine, substance P, and heparin.



The one which we have traditionally focused on is histamine.  Histamine is the same stuff that our bodies, and those of our canine companions, release during an allergic reaction.

It does bad things like create swelling, redness, pain, blood pressure changes, vomiting, loss of appetite, acid stomach, and more.

Much of the sickness that dogs afflicted with mast cell tumors suffer from is caused by histamine excess.

Some focus has been placed on blocking the effects of histamine with various medications.  However, very little has been placed on cutting off the body’s supply of histamine.

This is an intriguing and quite novel approach to dealing with histamine excess, and to my knowledge has not been tried in dogs.   So here’s the info…give it a try, see if it helps the dog you love, and let our community know!

The basic story is you cut out foods that eventually end up increasing active histamine levels,  by hook or by crook.  Now, most of you know that carbohydrate restriction is important is helping with cancer generally.  I discuss details of the dog cancer diet at length in the e-book, The Dog Cancer Survival Guide.


For more helpful tools and information, get a copy of the Dog Cancer Survival Guide


Here’s a new twist for those caring for a dog with a mast cell tumor diagnosis, especially the more aggressive ones (Grade 2 and 3).

Turns out there is some cutting edge new research going on in human medicine about ways to combat digestive upset, depression, anxiety, allergies, asthma, and more.  Many cases of these syndromes involve excessive histamine effects in the body.  There are very few diseases like mast cell tumors in people, but we humans do suffer from a close relative of mast cell tumors called systemic mastocytosis.

Anyway, those in the inner circle promote cutting off the wellspring of histamine in the body by simply not eating foods that promote histamine levels. Why not use a similar approach for dogs with mast cell tumors, another condition with histamine excess?

The biggies are those foods that are fermented as a part of processing.  Dogs usually don’t eat or drink a lot of those (drinks with alcohol, the more “moldy” of the cheeses like blue, sauerkraut, and vinegar).

But…. there are some out there who feed their dogs tofu.  Be careful!  Practically speaking, tofu could be viewed as a histamine brick.

Another big no-no, if one were using this approach, is fish!  Bacteria in the intestine of fish are quite busy making a lot of histamine, and levels rise after the fish passes away (but before the remains are gutted for food).


To learn more about Mast Cell Tumors, diet, and treatment options, get a copy of this seminar!


Dyes in food and the benzoates (BHT, BHA, sodium benzoate, benzoic acid) are also excluded from the diet.  Read those labels!

Note that the items on the restricted list not only contain histamine, but also are more prone to causing mast cells to release their illness-causing histamine reserves.  This only matters if there is a large mast cell burden (lots of tumor cells in the body) and we are wanting to lessen histamine release. In addition, this is all extrapolated from human information.  The inappropriate human foods should be excluded from the dog diet even if the list says they are “ok”.

I hope this helps-

Best,

Dr D

Leave a Comment





  1. Dallas Ryan on August 15, 2017 at 9:56 am

    What is histamine overload? What happens to the dog if histamines are overloaded with mast cell tumor? (I.E. does the dog get bigger tumors again? does the itch more? Diarheaa?). thanks

  2. Wendy Anthony on June 23, 2016 at 10:52 am

    I wanted to thank Dr Dressler for this article. One year ago, I added sardines to my 4.5 year old mixed breed dog’s diet, thinking I was doing her health a favor. (I used the highest quality possible: wild caught, no salt added, in spring water, from a good region for low toxins, etc). Within two weeks, she started sprouting what my vet and I initially thought were sebaceous cysts due to the added fat. They turned out to be mast cell tumors. All tumors reversed and completely resolved once the sardines were discontinued except for one that had to be removed (malignant but low grade; clean margins). I had no idea about fish and histamines at the time, only that this new food source seemed linked to the tumors.

    This spring, my local health food store started carrying a hard goat cheese from France in convenient little strips which were perfect for training. About 2 weeks into that, bang, some small mast cell tumors made their appearance. This was the only dietary change she had. I stopped the cheese and all the tumors resolved after about 6 weeks. At the same time, I found this article. Now I know only fresh cheese like mozzarella may be safe for a dog like mine but also realize what may have happened with the sardines.

    Outside of those two episodes, my dog has not had mast cell tumors. I am very controlling about her diet: carefully constructed homemade, mostly raw and mostly 100% grass fed and finished human-grade meat. Plus, she is with me almost 24-7 and I’m a highly watchful owner, so it was easy for me to isolate the fish and cheese as possible culprits. I know n=1 is fairly meaningless, but in her case, there seems to have been a very strong correlation between the two times she has sprouted MCT’s and those two particular dietary components.

    Thank you!

  3. I Switched From Store-Bought Dog Food to Homemade — Please Help! | Jeffrey Welch's Blog on October 9, 2015 at 4:28 am

    […] her tumors, which are mast cell. You can read more about histamines, mast cell tumors, and diet in this article by the guide’s co-author, Dr. Demian Dressler, and in this article by animal health consultant Susan […]

  4. Jana Lynn on October 26, 2014 at 7:17 am

    Thank you for taking your time to share this knowledge. My girl has been suffering from grade one and grade two mast cell tumors. Palladia is presently very successful, along with several surgeries, but it is amazing to know I can be doing more to reduce the risk of recurrence

  5. Susan Kazara Harper on September 24, 2014 at 1:19 pm

    Hi Val, If you’re vet is happy with the ingredients in the Wal-dryl, let that guide you. I can only suggest that if there is any doubt with your vet, check other manufacturers of Benadryl to find one that doesn’t contain the sodium benzoate. Your vet should be able to help with that. All the best luck for you and your Pug!

  6. Val on September 22, 2014 at 1:10 pm

    Hi. I have a nearly 15 year old Pug who has just been diagnosed with an intradermal MCT in her jowelCytology reports said cells were “fairly well differentiated”-perhaps grade I or II. X-rays and abdOminal ultrasound did not appear to indicate metastasis and our vet said her lymph nodes were small. Our vet suggested a Benedryl regimen right off the bat and we have been giving her daily a teaspoon or so of children’s formula wal-dryl (store brand of Benedryl). My question for you is this: the article suggests avoiding benzoates in the diet but one of the ingredients in Benedryl is sodium benzoate. Is this considered an exception then?
    Thank you

    • Diann McBee on September 17, 2015 at 11:01 pm

      Make sure your children’s benadryl does not contain xylitol (sweetener). Toxic to dogs.

  7. Tammy on March 22, 2014 at 12:43 pm

    Hi
    I have an 11 year old collie cross and I found a lump 3 weeks ago. I took her to the vet the next day and within three days it was tested and removed. The test came back as grade two and therefore they tested the lump further and found that it was 5.8% aggressive. I don’t really understand how bad this is so any advice on this would be appreciated. She has now been referred to a specialist who will look to do an ultrasound and spleen test. I have gone out and bought natures menu chicken, trip, veg and rice raw food today which comes in little frozen cubes which you defrost on a daily basis. They have loads of options and I was wondering the best to go with? Should I avoid carbs for example? Also is there any effective supplements I can give her? I am giving her garlic with fenugreek and mixed veg tablets at the moment.
    Thank you in advance 🙂 Tammy and Tara

  8. brittandpuggle on March 12, 2014 at 3:26 am

    Hello,

    I have found that honest kitchen “thrive” and “keen” have the lowest amount of histamine releasers. They aren’t grain free as they contain rolled oats and quinoa. They are also not as high in fat and protein as the others. Is this ok? Is there a way to suppliment if not? Also, are those particular grains ok? Thanks again for all the information!

    • Susan Kazara Harper on March 17, 2014 at 12:55 am

      Hello again, You’re doing great, investigating the various foods for your dog with MCT. Rolled oats are one of Dr. Dressler’s recommended grains and on the ‘ok’ list for MCT. Of course organic is better if possible. We’re still checking all the resources on quinoa and will let you know as soon as we have a good recommendation. All the best to you and Puggle!

  9. Susan Kazara Harper on March 6, 2014 at 8:08 am

    Apocaps has the perfect amount of tumeric plus other incredible ingredients, specially designed to help dogs in Puggle’s situation. And Aloha Medicinals provide an amazing mushroom-based supplement (Cordyceps). You can find both at http://www.dogcancershop.com. Do you have The Dog Cancer Survival Guide?

    • brittandpuggle on March 17, 2014 at 7:42 am

      Thanks for all your help Susan! I am going to check out the supplements suggested. I did purchase the book, it has been very helpful!

    • Nancy Yanez Walker on October 23, 2017 at 8:55 am

      So because Apocaps has turmeric is using Golden Paste overkill?

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