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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

DogCancer.TV: Palladia™ and Dog Cancer- What You Need to Know

Are you familiar with Palladia for dogs? Dr. Ettinger and Dr. Dressler discuss the use of Palladia, an FDA approved drug for dogs, as a chemotherapeutic treatment for dog cancer. Watch this video.

Transcript of: Palladia™ and Dog Cancer- What You Need to Know

James Jacobson: One of the more common drugs that’s used in cancer therapy is one that is only recently come to market it’s called “Palladia”, and let me ask you first Dr. Ettinger, tells us a little bit about Palladia and your thoughts on that.

Dr. Susan Ettinger: Yeah, Palladia is a really exciting new drug for a lot of different reasons. First, it is the first FDA approved drug for dogs. Most of the other cancer, anticancer therapies that we use in dogs so your traditional chemotherapy drugs were designed for people and over the years, we’ve learned how to give safely in dogs. So, Palladia was designed for dogs, and it was actually targets a mutation that about a third to a half on dogs with mast cell tumors have. So it’s a class of drugs called secret inhibitors and it targets its mutations that some dogs with mast cell tumors have.

James Jacobson: Okay, you use it for what kinds of cancers?

Dr. Susan Ettinger: Well, obviously, the number one cancer that we use it for is dogs with skin or cutaneous mast cell tumors. But we’ve also learned that this drug inhibits some of the other antiangiogenic receptors. So, it can be use or something called antiangiogenesis. So, we’re learning as a drug has been available for about 2 years now that it’s having some efficacy for some other cancers specifically fibrocarcinomas, anal sac carcinomas, and osteosarcomas. So, it’s being use a little bit more wide spread than it was initially designed for.

James Jacobson: Ok, and Dr. Dressler, what are your thoughts about Palladia?

Dr. Demian Dressler: I think Palladia has its certainly has its place in the tool box that we have available for treating canine cancers. It got a lot of press because it was the first drug and as such became very well known the first drug approved for canine cancer. Now, we should understand that most of the drugs that we use in conventional cancer care in dogs are actually human drugs that approved for use in humans and maybe more frequent than the use of Palladia.

James Jacobson: Ok. Now, there are some interesting side effects from Palladia, in cautions related to Palladia, right? Do you wanna pick up on that?

Dr. Susan Ettinger: Well, Palladia is an oral medication that you’re giving at home. Usually, every other day or on a 3 time-a-week schedule. So, commonly we’re using it Monday, Wednesday, and Friday. So, most of the time when we’re administering injectable chemotherapy at the office, if their dogs gonna get side effects, it’s usually gonna be within the first couple of days, and within a couple of days the dog has gonna get over those side effects. With Palladia, since it’s continually, continuously being given by the guardian at home, those side effects can continue to build up and it’s really important if your pet’s having any side effects. Weight loss, vomiting, diarrhea, changes in appetite or energy that you contact your veterinarian and you stop the medication. It is more important to give the pet a Palladia holiday than to keep plowing through the side effects. So, it’s really important to early recognition of side effects. Stop the medication, and then contact your Oncologist or your Veterinarian who’s managing the case with you.

James Jacobson: Dr. Dressler?

Dr. Demian Dressler: Absolutely! And, if one digs a little bit either in conversation with the Oncologist or even online. There are data available that give you the odds, the statistics. Ok, what are the odds of getting a side effect? Then, I think with palladia it’s a 30/40% or something like that of some sort of GIFs, vomiting or diarrhea. These types of thing and there are more rare and more serious one as well that you can find. It is important that as a guardian if you don’t understand exactly what that means? Dr. Ettinger operates in the area of chemotherapy and as such for her it could be that seeing a dog who’s vomiting it would be more routine because that’s something that does come out from time to time. But as a guardian, one of the duties is to ask yourself, “Ok… am I prepared for this”? As long as you’ve prepared yourself for what’s going, then at that point you can make a decision. But, always ask. Ask, ask, ask. Get the data that you need.

James Jacobson: Ok. I guess final question Dr. Ettinger I’ll throw this to you. What’s the price tag for Palladia?

Dr. Susan Ettinger: Well, that probably will depend a little bit on what part of the country you’re in. But, in general for about a 70 pound dog who’s on the medication either 3 times a week or every other day. Just for their drug itself, you’re probably looking at about 500 dollars per month. So, I have to say in this spectrum of some of the other injectable drugs, it’s pretty, moderately priced, but moderately priced. It’s not one of the most expensive drugs that we have.

James Jacobson: Ok. Dr. Ettinger of New York, Dr. Dressler in Hawaii, thank you so much for being with us. More information, a lot more information on Palladia and all sorts of different cancer treatments both chemotherapy and natural in The Dog Cancer Survival Guide. Thank you both.

Dr. Demian Dressler & Dr. Susan Ettinger: Thank you.

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Leave a Comment

  1. M Vouis on May 19, 2020 at 12:43 am

    Palladia is a brutal, side-effect riddled drug and has created more suffering than benefit for us. My 8 yr old Shar Pei Cross had a Mast Cell Tumour, Grade 2, mitotic count 8 removed in Jan 2020. It had moved into the lymph node on her right front paw. Initially I avoided chemo because it generally creates a cascade of other diseases and my oncologist was honest enough to advise its success was less than 30%. A terrible deceptive drug, promises much and delivers poison. My dog suffered terribly on the drug. It did shrink the lymph but it caused lameness: what quality of life does a dog have if it can’t walk or run. We took the manufacturer’s Palladia holiday. We started again and now she has completely lost her appetite and maybe her will to live. What is worse, the company does not give advice about adjunct therapies which would ease the mountain of side effects. E.g. I found that Vit B and magnesium helped her lameness. Why do they not give you advice about these things? It seems negligent to me. Think carefully before embarking on a trip full of trials but negligeable outcomes. I now a good intergrative vet and / or naturopath, do this as early as you can, one who will give you an integrated naturopathic and allopathic programme for treatment. Dr Dressler’s book – Dog Cancer Survival Guide is a must read.I am also exploring the apoptosis possible through Sodium Dichloroacetate – under supervision from a professional naturopath. Re Cost: Palladia is not moderately priced: in Australia it is min $600 per month plus $400 for the blood tests, plus a chemist shop full of other expensive medications to manage the flood of side effects and above all – suffering, suffering, suffering for your beloved pet and family. Beware!!!

    • June on February 13, 2021 at 3:02 pm

      Hello, How long was your dog on Palladia? Did you take him off of it when he started having these side effects? Once you took him off of it, did he return to normal and the side effects go away?

  2. […] chemo with a new drug called Palladia.  (approx: $380 a month but treatment is done at home via […]

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