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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Soft Tissue Sarcomas

Updated: November 14th, 2018

Soft Tissue Sarcoma (STS) is a type of tumor that can develop in a variety of connective tissues, muscles and fat. An STS can be found almost anywhere on the body, and a majority are aggressive locally, meaning they invade the surrounding tissues. STS are also prone to recur. To write her chapter on Soft Tissue Sarcoma in The Dog Cancer Survival Guide, Dr. Susan Ettinger consulted many studies, articles and books. Below is a list of the most important references.

Please note that in vivo and clinical use citations were included whenever possible. We have also include links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.

Soft Tissue Sarcomas. Selting KA, in Henry CJ, Higginbotham ML (ed): Cancer Management in Small Animal Practice. Missouri. Saunders Elsevier 2010, p 321-325.

Soft Tissue Sarcomas. Liptak JM, Forrest LJ. Withrow SJ, Vail DM (eds): Withrow & MacEwen’s Small Animal Clinical Oncology. St Louis Missouri, Saunders Elsevier, 2007, pp 425-454.

Soft-Tissue Sarcomas. Farrelly J, in Cote E (2nd ed), Clinical Veterinary Advisor: Dogs and Cats. Missouri, Mosby Elsevier, 2011, p 1064-1035.

Medical Management of Soft Tissue Sarcomas. Rassnick KM. Vet Clin Small Anim 33: 517-531, 2003.

Principles of treatment for Soft-Tissue Sarcomas in the dog. Ettinger SN. Clin Tech Small Anim Pract 18:118-122, 2003.

Prognostic significance of intratumoral microvessel density in canine soft-tissue sarcomas. Luong RH, Baer KE, Craft DM, Ettinger SN, et al. Vet Pathol. 43(5):622-31. 2006

Association of argyrophilic nucleolar organizing regions, Ki-67, and proliferating cell nuclear antigen scores with histologic grade and survival in dogs with soft tissue sarcomas: 60 cases (1996-2002). Ettinger SN, Scase TJ, Oberthaler KT, et al. J Am Vet Med Assoc. 228(7):1053-62. 2006

Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986-1996). Kuntz CA, Dernell WS, Powers BE, et al. J Am Vet Med Assoc 211: 1147-1151, 1997

Radiation treatment for incompletely resected soft-tissue sarcomas in dogs. McKnight JA, Mauldin GN, McEntee MC, et al. J Am Vet Med Assoc 217:205-10, 2000

Prognosis after surgical excision of canine fibrous connective tissue sarcomas. Bostock DE, Dye MT. Vet Pathol 17:581-8, 1980

Radiotherapy of soft tissue sarcomas in dogs. McChesney SL, Withrow SJ, Gillette EL, et al. J Am Vet Med Assoc 194:60-3, 1989

Postoperative radiotherapy for canine soft tissue sarcoma. Forrest LJ, Chun R, Adams WM, et al. J Vet Intern Med 14:578-82, 2000

Efficacy of mitoxantrone against various neoplasms in dogs. Ogilvie GK, Obradovich JE, Elmslie RE, et al. J Am Vet Med Assoc 198:1618-21, 1991

Phase II evaluation of doxorubicin for treatment of various canine neoplasms. Ogilvie GK, Reynolds HA, Richardson RC, et al. J Am Vet Med Assoc 195:1580-3, 1989

Soft tissue sarcomas and mast cell tumours in dogs; clinical behaviour and response to surgery. Baker-Gabb M, Hunt GB, France MP. Aust Vet J 81:732, 2003.

Immunohistochemical and histopathologic features of 14 malignant fibrous histiocytomas from Flat-Coated Retrievers. Morris JS, McInnes EF, Bostock DE, et al. Vet Pathol 39:473, 2002

Histopathological survey of neoplasms in flat-coated retrievers, 1990 to 1998. Morris JS, Bostock DE, McInnes EF, et al. Vet Rec 147:291, 2000

Outcome of dogs with high-grade soft tissue sarcomas treated with and without adjuvant doxorubicin chemotherapy: 39 cases (1996-2004). Selting KA, Powers BE, Thompson LJ, et al. J Am Vet Med Assoc 227:1442, 2005.

Metronomic therapy with cyclophosphamide and piroxicam effectively delays tumor recurrence in dogs with incompletely resected soft tissue sarcomas. Elmslie RE, Glawe P, Dow SW. J Vet Intern Med. 22(6):1373-9. 2008

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