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Featuring Demian Dressler, DVM and Susan Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Modified Citrus Pectin

Updated: October 4th, 2017

There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide. Here is a list of the most important references about modified citrus pectin.

Citrus pectin is a natural compound found in plants including apples, plums and citrus peels. In original form, pectin can’t be absorbed by the body. When slightly altered, pectin can enter the bloodstream.

Please note that in vivo and clinical use citations were included whenever possible. We have also include links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Glinsky VV, Raz A. Carbohydr Res. 2009 Sep 28;344(14):1788-91. Epub 2008 Sep 26. Review.

Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. Nangia-Makker P, et al. J Natl Cancer Inst. 2002 Dec 18;94(24):1854-62.

Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. Pienta KJ, et al. J Natl Cancer Inst. 1995 Mar 1;87(5):348-53.

Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model. Liu HY, Huang ZL, Yang GH, Lu WQ, Yu NR. World J Gastroenterol. 2008 Dec 28;14(48):7386-91.

Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. Guess BW, Scholz MC, Strum SB, Lam RY, Johnson HJ, Jennrich RI. Prostate Cancer Prostatic Dis. 2003;6(4):301-4.

Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response. Markowska AI, Liu FT, Panjwani N. J Exp Med. 2010 Aug 30;207(9):1981-93.

PectaSol-C modified citrus pectin induces apoptosis and inhibition of proliferation in human and mouse androgen-dependent and- independent prostate cancer cells. Yan J, Katz A. Integr Cancer Ther. 2010 Jun;9(2):197-203.

Pectin induces apoptosis in human prostate cancer cells: correlation of apoptotic function with pectin structure. Jackson CL, et al. Glycobiology. 2007 Aug;17(8):805-19.

The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Zhao ZY, et al. Altern Ther Health Med. 2008 Jul-Aug;14(4):34-8. Erratum in: Altern Ther Health Med. 2008 Nov-Dec;14(6):18.

Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification–five case reports. Eliaz I, Weil E, Wilk B. Forsch Komplementmed. 2007 Dec;14(6):358-64.

The effect of modified citrus pectin on urinary excretion of toxic elements. Eliaz I, et al. Phytother Res. 2006 Oct;20(10):859-64.

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