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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide


Updated: June 28th, 2018

There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide. Here is a list of the most important references about the use of luteolin, a flavonoid found in plants such as peanut hulls (the red skin surrounding the nut), chrysanthemums, and many other plants, fruit and vegetables. Numerous published research papers are now available showing that luteolin can boost the process of apoptosis, which is critical to health.

Please note that in vivo and clinical use citations were included whenever possible. We have also include links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.

Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling. Pandurangan AK1, Ananda Sadagopan SK, Dharmalingam P, Ganapasam S. Toxicol Mech Methods, 2014 Jan;24(1):13-20. doi: 10.3109/15376516.2013.843111. Epub 2013 Oct 7.

Luteolin Supplementation Modulates Mammary Tumor Growth in C3H Mice Fed Diet with High- and Low-Fat Content. Song MJ1, Lee EJ, Yang Y, Sung MK. Nutr Cancer. 2013 Sep 27. [Epub ahead of print]

Luteolin enhances paclitaxel-induced apoptosis in human breast cancer MDA-MB-231 cells by blocking STAT3. Yang MY1, Wang CJ2, Chen NF3, Ho WH4, Lu FJ3, Tseng TH5. Chem Biol Interact. 2014 Feb 11;213C:60-68. doi: 10.1016/j.cbi.2014.02.002. [Epub ahead of print]

Luteolin sensitises drug-resistant human breast cancer cells to tamoxifen via the inhibition of cyclin E2 expression. Tu SH1, Ho CT, Liu MF, Huang CS, Chang HW, Chang CH, Wu CH, Ho YS. Food Chem. 2013 Nov 15;141(2):1553-61. doi: 10.1016/j.foodchem.2013.04.077. Epub 2013 May 2.

Phosphorylation and stabilization. Shi R, et al. Mol Cancer Ther. 2007 Apr;6(4):1338-47.

Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line. Wu B, et al. Mol Cell Biochem (2008) Jun;313(1-2):125-32. Epub 2008 Apr 9.

Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells. Du GJ, et al. Biochem Biophys Res Commun. 2008 Aug 1;372(3):497-502

Radiosensitization effect of luteolin on human gastric cancer SGC-7901 cells. Zhang Q, et al. J Biol Regul Homeost Agents. 2009 Apr-Jun;23(2):71-8.

Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. Shimoi K, et al. FEBS Lett. 1998 Nov 6;438(3):220-4.

Distribution and biological activities of the flavonoid luteolin. López-Lázaro M. Mini Rev Med Chem. 2009 Jan;9(1):31-59. Review.

Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract. Chen T, et al. J Agric Food Chem. 2007 Jan 24;55(2):273-7.

Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin. Zhou P, et al. J Agric Food Chem. 2008 Jan 9;56(1):296-300.

Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Ueda H, Yamazaki C, Yamazaki M. Biol Pharm Bull. 2002 Sep;25(9):1197-202.

Luteolin, a flavonoid with potentials for cancer prevention and therapy, Lin Y, et al. Curr Cancer Drug Targets. 2008 November; 8(7): 634–646.

Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Chowdhury AR, et al. Biochem J. 2002 Sep 1;366(Pt 2):653-61.

Design of new anti-cancer agents based on topoisomerase poisons targeted to specific DNA sequences. Arimondo PB and Hélène C. Curr Med Chem Anticancer Agents. 2001 Nov;1(3):219-35. Review.

Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells. Horinaka M, et al. Oncogene. 2005 Nov 3;24(48):7180-9.

Luteolin induces apoptosis in oral squamous cancer cells. Yang SF, et al. J Dent Res. 2008 Apr;87(4):401-6.

Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin. Chiang CT, Way TD, Lin JK. Mol Cancer Ther. 2007 Jul;6(7):2127-38.

Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. Hu C and Kitts DD. Mol Cell Biochem. 2004 Oct;265(1-2):107-13.

Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Fang J, et al. Carcinogenesis. 2007 Mar;28(3):713-23. Epub 2006 Oct 25.

Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Chen CY, et al. Life Sci. 2007 Nov 30;81(23-24):1602-14.

Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Zhou Q, et al. Mol Cancer Ther. 2009 Jun;8(6):1684-91.

Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Michels G, et al. Toxicology. 2005 Jan 31;206(3):337-48.

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