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Featuring Demian Dressler, DVM and Susan Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Digestive enzymes as cancer treatments

Updated: November 22nd, 2017

There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide. Here is a list of the most important references about digestive enzymes as cancer treatments.

Please note that in vivo and clinical use citations were included whenever possible. We have also included links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.

Bromelain’s activity and potential as an anti-cancer agent: Current evidence and perspectives. Chobotova K, Vernallis AB, Majid FA. Cancer Lett. 2010 Apr 28;290(2):148-56. Epub 2009 Aug 22. Review.

Bromelain: biochemistry, pharmacology and medical use. Maurer HR. Cell Mol Life Sci. 2001 Aug;58(9):1234-45. Review.

Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients. Eckert K, et al. Oncol Rep. 1999 Nov-Dec;6(6):1191-9.

On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects. Lotz-Winter H. Planta Med. 1990 Jun;56(3):249-53. Review.

Bioavailability of 125I bromelain after oral administration to rats. White RR, et al. Biopharm Drug Dispos. 1988 Jul-Aug;9(4):397-403.

In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Báez R, et al. Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24.

Modulation of murine tumor growth and colonization by bromelaine, an extract of the pineapple plant (Ananas comosum L.). Beuth J, Braun JM. In Vivo. 2005 Mar-Apr;19(2):483-5.

Bromelain. Orsini RA; Plastic Surgery Educational Foundation Technology Assessment Committee. Plast Reconstr Surg. 2006 Dec;118(7):1640-4. Review.

Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway. Bhui K, et al. Cancer Lett. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31.

Bromelain reversibly inhibits invasive properties of glioma cells. Tysnes BB, et al. Neoplasia. 2001 Nov-Dec;3(6):469-79.

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