There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide. Here is a list of the most important references about the use of cimetidine.
Please note that in vivo and clinical use citations were included whenever possible. We have also included links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.
Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. Kobayashi K, et al. Cancer Res. 2000 Jul 15;60(14):3978-84.
Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine. Watson SA, et al. Gut. 1993 Aug;34(8):1091-6.
Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth. Adams WJ, Lawson JA, Morris DL. Gut. 1994 Nov;35(11):1632-6.
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. Matsumoto, S. et al. Br J Cancer. 2002 January 21; 86(2): 161–167.
Cimetidine in colorectal cancer–are the effects immunological or adhesion-mediated? Eaton D, Hawkins RE. Br J Cancer. 2002 Jan 21;86(2):159-60.
Characterization and development of cimetidine as a histamine H2-receptor antagonist. Brimblecombe RW, Duncan WA, Durant GJ, Emmett JC, Ganellin CR, Leslie GB, Parsons ME. Gastroenterology. 1978 Feb;74(2 Pt 2):339-47.
Does cimetidine improve prospects for cancer patients? A reappraisal of the evidence to date. Siegers CP, Andresen S, Keogh JP. Digestion 1999 Sep-Oct;60(5):415-21.
Evaluation of Cimetidine Treatment for Melanomas in Seven Horses. Preliminary Report 16 Refs. *Lorin D. Warnick, DVM, PhD, Mary E. Graham, DVM, and Beth A. Valentine, DVM, PhD. Equine Pract 17:16-22 Jul’95.
Cimetidine for the Treatment of Melanomas in Horses: Efficacy Determined by Client Questionnaire. Equine Pract 16:18-21 May’94. Retrospective Study 12 Refs. *Jonathan E. Hare; Henry R. Staempfli. Am J Clin Oncol 1991 Oct;14(5):397-9.
Phase II trial of cimetidine in metastatic melanoma. A Hoosier Oncology Group trial. Mandanas R, Schultz S, Scullin D, Einhorn LH. J Am Vet Med Assoc 1990 Feb 1;196(3):449-52.
Cimetidine for treatment of melanomas in three horses. Goetz TE, Ogilvie GK, Keegan KG, Johnson PJ. J Am Vet Med Assoc. 1990 Feb 1;196(3):449-52.
Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study. Marshall ME, Butler K, Cantrell J, Wiseman C, Mendelsohn L. Cancer Chemother Pharmacol 1989;24(1):65-6.
Regression of melanoma nodules in a patient treated with ranitidine. Smith T, Clark JW, Popp MB. Arch Intern Med 1987 Oct;147(10):1815-6.
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