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Featuring Demian Dressler, DVM and Susan Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Artemisinin

Updated: October 1st, 2018

There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide. Here is a list of the most important references about the use of artemisinin.

Please note that in vivo and clinical use citations were included whenever possible. We have also included links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.

Recent advances in artemisinin and its derivatives as antimalarial and antitumor agents. Jung M, et al. Curr Med Chem. 2004 May;11(10):1265-84. Review.

Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents. Chaturvedi D, et al. Chem Soc Rev. 2010 Feb;39(2):435-54. Epub 2009 Aug 24. Review.

Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo. Du, JH, et al. Cancer Chemother Pharmacol. 2010 April; 65(5): 895–902.

Artesunate in the treatment of metastatic uveal melanoma–first experiences. Berger TG, et al. Oncol Rep. 2005 Dec;14(6):1599-603.

Inhibition of angiogenesis in vivo and growth of Kaposi’s sarcoma xenograft tumors by the anti-malarial artesunate. Dell’Eva R, et al. Biochem Pharmacol. 2004 Dec 15;68(12):2359-66.

The anti-malarial artesunate is also active against cancer. Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR. Int J Oncol. 2001 Apr;18(4):767-73.

Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat. Lai H, Singh NP. Cancer Lett. 2006 Jan 8;231(1):43-8.

Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds. Lai H, Sasaki T, Singh NP. Expert Opin Ther Targets. 2005 Oct;9(5):995-1007. Review.

Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Mukanganyama S, Widersten M, Naik YS, Mannervik B, Hasler JA. Int J Cancer. 2002 Feb 10;97(5):700-5.

Toxic brainstem encephalopathy after artemisinin treatment for breast cancer. Panossian LA, Garga NI, Pelletier D. Ann Neurol. 2005 Nov;58(5):812-3.

What made sesquiterpene lactones reach cancer clinical trials? Ghantous A, et al. Drug Discov Today. 2010 Aug;15(15-16):668-78. Epub 2010 Jun 9.

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