Featuring Demian Dressler, DVM and Susan Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Antioxidants and Pro-Oxidants

Updated: October 1st, 2018

There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide. Here is a list of the most important references about the use of antioxidants and pro-oxidants.

Please note that in vivo and clinical use citations were included whenever possible. We have also include links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.

Antioxidant supplements for preventing gastrointestinal cancers. Bjelakovic G, et. al. Cochrane Database Syst Rev. 2008 Jul 16;(3):CD004183. Review.

Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. Albanes D, et.al. J Natl Cancer Inst. 1996 Nov 6;88(21):1560-70.

Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. Virtamo J, et. al. Taylor PR, Albert P; ATBC Study Group. JAMA. 2003 Jul 23;290(4):476-85.

Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Druesne-Pecollo N, et. al. Int J Cancer. 2010 Jul 1;127(1):172-84. Review.

Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Bjelakovic G, et. al. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD007176. Review.

Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Bjelakovic G, et. al. JAMA. 2007 Feb 28;297(8):842-57. Review. Erratum in: JAMA. 2008 Feb 20;299(7):765-6.

Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid. Sugihara N, et. al. Free Radic Biol Med. 1999 Dec;27(11-12):1313-23.

Free radicals, metals and antioxidants in oxidative stress-induced cancer. Valko M, et al. Chem Biol Interact. 2006 Mar 10;160(1):1-40. Epub 2006 Jan 23. Review.

Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death. Sun Y, Chen J, Rigas B. Carcinogenesis. 2009 January; 30(1): 93–100.

Breast cancer cell-targeted oxidative stress: enhancement of cancer cell uptake of conjugated linoleic acid, activation of p53, and inhibition of proliferation. Albright CD, et al. Exp Mol Pathol. 2005 Oct;79(2):118-25.

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Trachootham D, Alexandre J, Huang P. Nature Reviews Drug Discovery 8, 579-591 (July 2009)

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