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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Neoplasene as a Dog Cancer Treatment

Updated: May 24th, 2020

I received a question recently asking if I had heard of Neoplasene, so I thought I should post about it.

Neoplasene is derived from bloodroot, an old herb used by native Americans.  The stuff works but can be a bit much for an average dog lover to deal with.  Read on.

It is delivered to the dog cancer patient in a salve that is rubbed on the tumor, or pills, or can be injected in the vein or around the tumor.

It is different from so-called “black salve”, as Neoplasene is a specific extract of bloodroot, not the whole herb.  Only certain components of the plant are used.

There are a variety of successes documented, especially with tumors of the skin like fiborsarcomas, mast cell tumors, mammary tumors, and others.

Neoplasene is for use under veterinary supervision only.  This is a good call by the makers of the product (Buck Mountain Botanicals). The reason for this is, when the ointment is applied to the tumor on the skin, the tumor cells start to die.

When the tumor cells die, the tissue tends to slough off.  A hole is left which needs medical attention.  This hole can be pretty big, especially if the tumor was on the larger side.  Sometimes the defect produced after large sloughs can go down to the bone.  Kind of heavy-duty for some dog lovers.

For more helpful tools and information, get a copy of the Dog Cancer Survival Guide

Other factors need to be considered before using Neoplasene.  One is that your dog must not lick the ointment.  An Elizabethan collar may be needed, sometimes for a long time.  Another issue is the wound may need twice daily care.  Finally, there can be pain or discomfort after application or use of Neoplasene, which may require the use of prescription strength pain control medication, in some cases.

Like many tools in medicine, we need to consider all the pros and cons of this treatment.  For some dogs with cancer and those who love them, it may be a great match, but not necessarily for all.

I hope this information is helpful.  For more outside the box ways to deal with canine cancer, check out the dog cancer e-book, The Dog Cancer Survival Guide, Beyond Chemotherapy, Radiation, and Surgery.

Best to all,

Dr D


Leave a Comment

  1. Barbara on November 23, 2018 at 12:07 pm

    I’d like to ask, how can I buy Neoplasene? My dog Roza has osteosarcoma, she’ll finish chemotherapy in Decembre. We live in Poland. Thank you Barbara and Rosa

    • Dog Cancer Vet Team on November 26, 2018 at 7:50 am

      Hello Barbara,

      Thanks for writing. Your veterinarian, or a holistic vet, may be able to purchase Neoplasene on your behalf, or may know where you can purchase it. They will also be able to tell you whether Neoplasene can work alongside your dog’s current treatment plan 🙂

  2. […] found a holistic vet in Richmond that is treating her with neoplasene – a bloodroot treatment that is either injected or applied topically (we’ve done both) to […]

  3. […] found a holistic vet that is treating her with neoplasene – a bloodroot treatment that is either injected or applied topically (we’ve done both) to […]

  4. shakira001 on July 15, 2017 at 9:15 am

    Did Neoplasene with out 15 years old dog last year now going on 16 years old and he did amazing. Cancer tumor was gone in two weeks then the taken internally once we knew it worked to clean up any cancer. I did not want it biopsied because it spreads the cancer. We knew if the neoplasene worked on the tumor externally it was working. He is. like a puppy. I also have him on primalix products I distribute and a food that prevents cancer and creates apoptosis to existing cancer cells.

  5. Weslee on January 10, 2014 at 3:23 pm

    I have a cat with what my vet and I are assuming is an injection related sarcoma between his shoulder blades. After watching a tiny lump for a year, it suddenly grew into the size of about a Ping-Pong ball. Would he be a candidate for topical Neoplasene? We do not want to do surgery or chemo/radiation.

  6. Susan Kazara Harper on October 1, 2013 at 1:40 pm

    Jesse, these are the hardest times to go through. The bottom line is that no one can make this decision for you. You have fought hard and it’s obvious that you love your boy very much. You also know him better than anyone. I encourage you to sit down with him and just be still. Take a few deep breaths, and calm your mind, listen to your heart. Talk to him, tell him you are doing everything you can for him because you love him and want him to get better if he can. But also Jesse, every living being has a time to move on. Sometimes our animal companions love us so much that they fight really hard because they know we are too afraid of losing them. And that can become a burden to them. If you can take the pressure of your fear off your boy and ask him to let you know what he wants, you will very likely feel the answer in your heart. Sometimes just relaxing our own expectations and needs allows our animals to relax and feel a bit better, and sometimes it allows them to feel it’s OK to move on. When you talk to him, make sure you take the opportunity to laugh as you tell him how much joy all the years have been together. If you can step back from your grief, you will know what decision to make and when, and it will be from your boundless love. Give your boy a hug from me, and one for yourself.

  7. Jessie James-Hawley on September 30, 2013 at 7:05 pm

    My dog has been diagnosed as having cancer of the throat. He is a large dog, about 13 years old. Our vet has us giving him a black medicine labeled Neoplasene. We were told to give it to him in his food…50% cooked meat, 25% cooked rice and 25% cooked vegetables. He wouldn’t touch it. We finally injected the .35ml in baked hamburger meat balls. That worked for awhile, with a lot of struggle on his part and ours. Lately he won’t eat that at all. We were able to get him to eat other chopped up cooked meat, and he drinks water…but the past two nights I have been up with him all night. He couldn’t swallow..breathing was terribly difficult for him, it was agonizing for him to walk. In addition to the cancer they said he has an enlarged heart…that was two week ago. His eyes are gumming up…are we simply making him suffer by continuing with this treatment? I want to fight for him. We’ve had him stay at the vet’s for over a week until they got him stabilized…we’ve had him home now for almost a week, but to me he is running out of life. They said his cancer is terminal. When do we make a decision…is it right to continue with the treatment if we can’t see an improvement, or should we let him go??? His eyes are starting to him over…we clean them…I don’t know what he wants us to do?

  8. Savannah on September 12, 2013 at 7:08 am

    I have a 7-year old Great Dane who is everything to me and I just found out that he has a bone tumor(osteosarcoma) in his front left leg that is enveloping the ulna. Amputation is out of the question because of his large size and my vet has essentially just given me enough pain meds to give him until the end. But I’m searching the internet trying to find out if there could possibly be any other options out there for us. Even just something extra and topical I could use for the pain. Or something that could slow down the growth of the tumor. Essentially any other advice or help of any kind would be more than appreciated. Thank you.

    • James on March 24, 2015 at 11:22 am

      I have a 6 yr old Great Dane that has just been diagnosed with bone cancer in his left front leg aswell and im so sorry for you its not fun but thank god its not an internal cancer wich would have grown and grown until its too late, so we are blessed in a way, But I have done all sorts of research and am about to administer the neoplasene chemotherapy to my dog tomorrow because I just gave him pain meds and vitamins and the Doc said not to mix them… If you would like to learn what I have learned let me know but real quick I found that Sacred Frankincense can slow or stop the growth of cancer, I have heard several good outcomes from people who administered this to their animal that had cancer…Also you can try Amygdalin B-17 which is an extract from the apricot seed that releases syanide into the blood which has also had several great success stories plus an extra is raspberry seed in a pill which has many benefits and has many success stories…Plus AHCC which is a mushroom compound that helps the chemo paitent feel better and such…Now me personally I have decided to start with Neoplasene and plan to do it for 1 month then regroup and possibly do an I.V. treatment to kill any cancerous colonies in the lungs or anywhere else they may have spread but I will see how it shrinks the bone tumor and see if it is helping if it does help and doesnt make him too sick I willl continue it for another 1-2 months…But if I decide to stop treatment and go the natural way or just after the treatment plan is exhausted my plan is to get Boswellia Sacra Frankincense oil ($100) and AHCC ($40) and Raspex Raspberry Seed capsules ($27)…I hope these natural remedies will keep the cancer down and maybe cured with the help of God…These are my two treatment plans, hopefully they helped…God bless your dog, remember never give up on your pets, but dont feel bad if you did everything you can and were not successful its ok to put your pet to sleep if the pain is just unbearable and there is NO POSSIBILITY of rehabilitating to a better quality of life…he or she will be with you in heaven…

    • Kathy Snyder Guerke on June 9, 2015 at 8:35 am

      Hi Savannah,
      My 8 year old great dane also has a bone tumor on his right forefront(wrist area)..we have done radiation and a drip of pamidronate..he has a weak heart so amputation was not an option..what has happened with your girl? Any help would be appreciated..wondered anbout neoplasene, Kathy

    • Paula on August 5, 2015 at 10:07 am

      Search artemisinin. I just bought it in liquid form. It contains wormwood and black walnut. It sounds like a miracle. Goggle it. Maybe not a cure but surely a prevention from spreading. There is an abundance of information on the subject. Good luck to us all.

  9. Nicole on June 6, 2013 at 2:56 pm


    I’m treating my dog with lymphoma and exact same as you described. I’m using Neoplasene as well as mirtazapine, and prednisone. She’s made it a month so far and loves her new cancer diet. She looks pretty good in the eyes, but her face has become deflated from the pred. which saddens me to see, but her swelling went down almost instantly when put on it. Pred is a mask though and other things are still going on and her body is slowing. I was told I may only have a few months with her so we are trying to make the most of it. She still has her appetite so I know she is ok. Once that goes I know she is failing. She struggles some days with heavy breathing and it’s usually after a dose of neoplasene. She gets warm to the touch and then after several hours calms down. I give it orally. I hid it in her food as she hates the taste! She is on Apocaps, K9 Immunity, and Wobenzym. It’s very hard to know on her hard days weather its her cancer or the treatment bothering her. We try to keep things calm and I just know she may never be the same dog again. We limit rides in the car, which we did several times daily. Now we go days without going and it’s sad. I try to look at it as a time out vs a forever. But some days we just ride around and come home. She doesn’t walk near as far without needing water. Before she could go several hours or 1/2 day without water. She is noticeably different. I am fasting myself in order to clear my own body so that she feels no extra anxiety from me. I keep soft music on (monk chanting in fact) and we have a pretty sen life right now… Sending love!

  10. Cheryl on May 31, 2013 at 12:52 pm


    My 11-year-young Shetland Sheepdog, extremely fit and active, has been diagnosed with Lymphoma. Her lymph nodes on either side of her throat are about the size of two marbles and the nodes above her shoulders are about like cherry tomatoes. Nothing felt in the abdomen, groin or behind the knees. Pathology shows about 50% of her cells from the biopsy are the enlarged Lymphoma cells. Do you feel that Neoplasene would be of benefit to her? I’m simply devastated looking at my otherwise perfectly healthy and happy dog and thinking that the end could be near for her. Any help or advice is greatly appreciated. Thank you.

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