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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Luteolin and Dog Cancer, Continued

Updated: April 27th, 2020


A look at the cutting edge, new bioflavoniod luteolin, its application in cancer treatment, and a source.

This is the follow up to the last post about luteolin, a bioflavonoid found in several plants (celery, perilla, artichoke, peanut hull, chrysanthemum and others).

This stuff has a whole slew of literature supporting it’s use for cancer.

It is so new though that not many have heard of it in this country.

I have been using it with dogs with cancer and have been impressed with some of the results.  This of course is my clinical opinion, and is not meant to be  a blanket recommendation.

Why did I get interested? Well, the evidence in rodents and people point to some really good stuff! And to top it off, there seems to be harmony with chemotherapy agents.  Read on!

Cancers with a molecule on the outside of their cells called HER are pretty resistant to chemo.  Luteolin showed it could decrease the tumors in rodents with these tough cancers. Here’s the link.

Luteolin also was able to decrease prostate cancer cell growth in mice, as well as oral squamous cell carcinoma cells.  Check out this article here

I found another article that showed the same for liver cancer cells.  See for yourself!

For more helpful tools and information, get a copy of the Dog Cancer Survival Guide

So we have multiple different cancers all responding to luteolin in mice, and based on my research no significant adverse effects in 26 dogs so far. This is not that many in the broad scheme of things, but is pretty darned good anyway.

And this was all when it was given by mouth, in living bodies, not test tube or petri dishes, and not injected…

Finally, chemo effects were actually enhanced with cisplatin (read more), doxorubicin, and the human chemo drug paxlitaxe.

Luteolin is found in Apocaps, which was created for my patients and is now available.

As always, discuss medical decisions with your vet or oncologist before action, and I hope this helps!


Dr Dressler


Leave a Comment

  1. Fation Kaseja on March 21, 2022 at 7:18 am

    I wanted to ask you how can I give my dog ​​luteolin powder supplement please? what is the best way to absorb faster?

    • Molly Jacobson on March 21, 2022 at 10:44 am

      The best way to get luteolin is in a supplement that is formulated to be bioavailable. Apocaps is definitely a good choice:

  2. Ben on September 26, 2017 at 10:24 am

    That study is only about the use of graviola fruit and seed and it didn’t actually prove much in any case. Doesn’t apply to leaf and stem of the graviola that Raintree use.

  3. Daryl Holly on July 15, 2011 at 4:33 pm

    My dog, Tilda, is a Therapy Dog at 4 hospitals but about a month ago her first Mast Cell Tumor popped up on the back of her head and the vet found it on her regular exam. Lab results were positive. Since then every few days the number of Mast Cell Tumors would double and on last count there were over 115. At the vet’s advice I took her directly to CSU Vet Hospital in Fort Collins, Colorado about 3 weeks ago (after positive lab test). They diagnosed Tilda with Grade 3, Stage 3 Mast Cell Tumors. They decided not to operate as there are too many so they put her on 30mg Prednisone every other day plus she was started on weekly treatments of Vinblastine Intravenously. The Tumors keep getting bigger and bigger with some now the size of a sewing thimble. They are also having me give her something for stomach acid and 100mg Benedryl 4 times per day. The itching is now getting so bad, Tilda is breaking open many of them and it is getting worse day by day.

    CSU says she is on the last end of this tragic disease and are no longer of much help except to prescribe more drugs to do one thing which causes something else so need a drug to fix that. Way too much drugs and poor Tilda is losing ground. Her attitude is still good but she is not comfortable these days. Is there anything you can help with? This wonderful dog has done so much for other people…….hundreds of people. It is so sad to see her saddled with this horrible disease. I built a website for her about a year ago and the blogs section there tells about the stages of this disease plus a lot of personal experiences she has encountered helping people. I will leave the website name for Tilda is the space provided below my email address. Please help if you can think of anything?

  4. Stacy on November 2, 2010 at 10:04 pm

    Dr D,
    Thank you so much for sharing this, and other valuable information in the canine cancer fight. My 8 yr old ridgeback was diagnosed in June with osteosarcoma. We did amputation and followed with Chemo. We also do a high protein home cooked diet and lots of supplements. In particular, we are doing Vitamins A, C, E, D, L-glutamine, L-arganine, selenium, curcumin, broccoli seed extract, green tea extract, IP-6, agaricus blazie, miatake/reishi/shitake blend. I think that’s all of them!
    We also just started a low dose (100mg) in the evening of artemisinin – 3 hours away from his last food. If I want to incorporate luteolin, would I need to stop any of these? How about artemisinin with Luteolin?
    We’re likely going to start the metronomic protocol soon as well – would it be bad to be combining that with Luteolin? Very curious as the information in your book is really intriguing!

    Many thanks, again. Much of the information we have gathered has come from your blog and book – and we eternally grateful!

  5. Kathy on October 14, 2010 at 8:58 am

    Dear Dr. Dressler,

    Sorry for a couple of more questions –

    As I mentioned my dog has lymphoma, among the supplements you introduced in yur book, which do you consider are more effective for lymphoma?

    I tried artemisinin and curcumim. (I still gave my dog daily vatimins.) Curcumin does not do well with my dog, as he has stomach upsets. Curcumim was not absorbed by his body at all. I used liquid soy lecithin to help absorption already, but my dog got nauseous.

    I have not tried luteolin and EGCG and start thinking about switching to these soon. I tried to order Apocaps, but they do not ship to Canada.


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