There were many studies, articles and books Dr. Dressler and Dr. Ettinger used when writing The Dog Cancer Survival Guide. Here is a list of the most important references about the use of doxycyline.
Please note that in vivo and clinical use citations were included whenever possible. We have also include links to the papers, where available. Most of the papers are found on the National Institute of Health’s online library, PubMed.
Effect of doxycycline on bone turnover and tumor markers in breast cancer (BC) patients with skeletal metastases. Dhesy-Thind SK, et al. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. Vol 23, No 16S (June 1 Supplement), 2005: 3198
Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer. Duivenvoorden WC, et al. Cancer Res. 2002 Mar 15;62(6):1588-91.
Doxycycline and other tetracyclines in the treatment of bone metastasis. Saikali Z and Singh G. Anticancer Drugs. 2003 Nov;14(10):773-8. Review.
Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. Duivenvoorden WC, Hirte HW, Singh G. Invasion Metastasis. 1997;17(6):312-22.
Does doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer? Sagar J, et al. World J Surg Oncol. 2009 Jan 6;7:2.
Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme. Smith GN Jr, et al. Arthritis Rheum. 1999 Jun;42(6):1140-6.
Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. Golub LM, et al. J Clin Periodontol. 1995 Feb;22(2):100-9.
Effects of tetracyclines on angiogenesis in vitro. Fife RS, et al. Cancer Lett. 2000 May 29;153(1-2):75-8.
Doxycycline Induces Expression of P Glycoprotein in MCF-7 Breast Carcinoma Cells. Mealey,KL, et al. Antimicrob Agents Chemother. 2002 March; 46(3): 755–761