I have been posting on what a huge issue timing can be when it comes to dog cancer treatments.
In conventional cancer care, this area is utterly overlooked, except in Europe (especially France) and only a couple of spots in the US.
Why does it matter?
Well, dogs (as well as people, other animals, plants, algae, and “lower” life forms) have different things happening at different times in a 24 hour day.
This means that, universally, there are certain processes going on in the morning, afternoon, and night.
These processes influence the handling of drugs in the body very, very significantly. When you are talking about chemotherapy, this matters enormously.
Chemo drugs can have toxic effects, more so than most other drugs. If we can use them at certain times of the day when their toxicity is lower, we gain massive treatment ground!!
I spoke with the father of American chronotherapy, who gave me his best wisdom on the topic. Now, the times he came up with may not be in available publications, at least not yet. He was giving me the information so I could help dogs at my practice.
So, this information is from me. I am choosing to share it with you because I think that if these guidelines are followed, like the studies in rats and humans, we see massive side effect reduction, and better effects in dogs with cancer!
For more helpful information and tools, get a copy of the Dog Cancer Survival Guide
Please understand this whole science is new, and for most Americans, pretty much unheard of.
So don’t be surprised when your vet or oncologist has no clue what you are talking about. But please rest assured, like everything in this blog, chronotherapy is not whoo-hoo mumbo jumbo. It has been demonstrated in good quality scientific studies.
Here they are*:
CCNU (Lomustine) :
Doxorubicin (Adriamycin): early AM
Platinum Drugs (Cisplatin, Carboplatin):
Corticosteriods (Prednisolone, Prednisone, Dexamethasone, Triamcinolone): early AM
5-FU: middle of the night
: early AM
Vinca Alkaloids (Vincristine, Vinblastine): Mid-Day
*based on human and rodent studies.
Use this information and share it with your vet or oncologist!
Dr. Demian Dressler is internationally recognized as “the dog cancer vet” because of his innovations in the field of dog cancer management, and the popularity of his blog here at Dog Cancer Blog. The owner of South Shore Veterinary Care, a full-service veterinary hospital in Maui, Hawaii, Dr. Dressler studied Animal Physiology and received a Bachelor of Science degree from the University of California at Davis before earning his Doctorate in Veterinary Medicine from Cornell University. After practicing at Killewald Animal Hospital in Amherst, New York, he returned to his home state, Hawaii, to practice at the East Honolulu Pet Hospital before heading home to Maui to open his own hospital. Dr. Dressler consults both dog lovers and veterinary professionals, and is sought after as a speaker on topics ranging from the links between lifestyle choices and disease, nutrition and cancer, and animal ethics. His television appearances include “Ask the Vet” segments on local news programs. He is the author of The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog’s Life Quality and Longevity. He is a member of the American Veterinary Medical Association, the Hawaii Veterinary Medical Association, the American Association of Avian Veterinarians, the National Animal Supplement Council and CORE (Comparative Orthopedic Research Evaluation). He is also an advisory board member for Pacific Primate Sanctuary.