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Featuring Demian Dressler, DVM and Sue Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide

Food and Nutrition for Dogs with Mast Cell Tumors

Updated: August 24th, 2023

Summary

Dr. Dressler’s Dog Cancer Diet is appropriate for most dogs, but dogs with mast cell tumors need a few modifications. Read this if your dog needs a low-histamine diet.

We know that good nutrition is the foundation of health. The Dog Cancer Survival Guide devotes an entire chapter to a real food diet for our dogs battling cancer, advising both on the foods to give, and those to avoid.

Dogs with Mast Cell Tumors MAY Need a Low-Histamine Diet

While every cancer journey is a tough one, the diagnosis of Mast Cell Tumor (MCT) presents a bigger challenge when it comes to feeding.

In some (not all!) mast cell cancers, large amounts of histamine are released in the body, causing irritation and itching. In addition to itchies on the skin, the irritation can also be found in the gut.

That can cause nausea, vomiting, and diarrhea.

Antihistamines May Help (and Are Often Prescribed)

Most MCT treatment protocols include an antihistamine to help block histamine receptors.

So why look at diet, if you are giving an antihistamine?

Well, some foods have high histamine levels that can irritate the tummy tissues. Others may trigger the release of histamines in the body.

If your dog is itchy and/or having GI issues, making some of the modifications listed below might help.

The Dog Cancer Diet Is Fantastic for Mast Cell Tumors … With a Few Modifications

Even some of the healthiest, highest recommended foods Dr. Dressler recommends in his diet may not be appropriate for a dog with MCT.

If your dog is itchy and scratchy, Dr. Dressler’s post on Diets for Dogs with Mast Cell Tumors addresses this cause and effect in more depth.

Dr. Dressler has also provided insights for and reviewed this article, as well. The guidelines below will help you to modify his diet for your dog.

But first, let’s review when histamine is a problem … and when it is not.

 

Histamine … Is It a Problem for Your Dog?

First, it’s important to know that just because your dog has MCT doesn’t mean your dog is automatically having a problem with histamine levels.

Not all dogs with MCT have histamine problems!

Histamine is an important part of the body’s normal functioning. It’s made in several ways. It doesn’t just come from the diet.

That’s important to keep in mind. Changing the diet won’t necessarily eliminate histamine. It will just keep you from adding MORE histamine.

Put another way, if you have a sunburn, you don’t go out in the sun and try to get a tan, right? You avoid the sun until your burn has healed.

Same thing here. If your dog is in histamine overload, you avoid high histamine foods until those levels go down.

Signs Your Dog Is In Histamine Overload

So how do you know if your dog is in histamine overload, and you should change the diet?

If your dog is currently vomiting, itching, feeling sick, having reduced appetite, or swelling (welts) … histamine is probably in overload.

Signs Your Dog Is NOT In Histamine Overload

If your dog seems calm, isn’t itchy and scratchy, is eating and eliminating normally, has normal skin tone, and is basically acting fine … she is likely not in histamine overload.

Also, if there are no or few Mast Cell Tumors … for example if you’ve surgically removed them all … he’s almost certainly not in histamine overload.

Reducing dietary histamine is not necessary if your dog is not in histamine overload.

Why? Well, MOST of the ingredients in Dr. Dressler’s dog cancer diet are already on the low-histamine list. It’s already a pretty low-histamine diet as it is …

… and there are only a couple of ingredients that are high in histamine. And those are important sources of some vitamins and minerals … so if you don’t have to eliminate them, it’s way easier.

Balancing Act: Mast Cell Tumor Dogs May Go In and Out of Histamine Overload

In a way, histamine manages water flow in the body. When it is released, the area will swell, bringing immune activity.

For example, histamine is one of the things that causes a bug bite to swell up. It’s helping to heal. When it’s no longer needed, the body stops manufacturing it. The tissues stop swelling.

Mast cells that have tumors in them do not always manufacture and release more histamine. Sometimes, they don’t do that at all.

Sometimes they do, but then the antihistamine you give helps them to stop.

So this is not an all or nothing situation. You may not have to deal with histamine overload at all. Or you may have to deal with it for a couple weeks, and then stop.

How to Decide Whether to Use a Low Histamine Diet for Dogs with Mast Cell Tumors

So … it’s pretty simple.

If your dog has high histamine symptoms, reduce histamine in food. Again, you won’t be treating the problem … you just won’t be adding more histamine unnecessarily.

If your dog stops having symptoms (or if your dog never has any symptoms), you can resume a normal dog cancer diet. Again, dietary histamine is not likely going to trigger a problem if one doesn’t already exist.

The histamine problems in mast cell tumor dogs are coming from the cancer, not from the diet … reducing histamine in the diet is about reducing unnecessary excess, not about treating the cancer.

So you may only need to modify your dog’s diet for a little while. Once symptoms stop, and your dog is feeling better for a few days or a week, try adding one item back in and see how she does. If she tolerates it, you can continue feeding those few higher-histamine items.

If you see itching, or tummy upset start up again, you can remove those higher-histamine items again.

Rarely, a dog needs to have a low-histamine diet on a regular basis. In those cases, you’ll see itching and other symptoms start up as soon as you stop a low-histamine diet. In those cases, you want to keep a low-histamine diet for as long as necessary to keep your dog comfortable.

Like most things, this is all about balance and is not a yes/no/black/white topic.

The bottom line: Follow the symptoms, and feed accordingly.

Low Histamine Dietary Guidelines for Dogs with Mast Cell Tumors

It’s surprising just how tough it has been to find more thorough information on what foods to give a dog with MCT.

I honestly don’t know whether this is because no one wants to publish a recommended list, or no one has thought of it yet. But I know the need is there because our readers are asking for it.

Must-Understand Concepts for a Low Histamine Dog Cancer Diet

With Dr. Dressler’s expert input and my own background with animal nutrition, I’m going to give you a list of foods to avoid (and to choose).

As long as you promise to note the following:

  • Follow the recommended proportions/amounts in Dr. Dressler’s diet. Don’t go overboard on any ingredient in the yes list below. Five pounds of Brussels sprouts at a time is not good … even though they are on the “ok” list.
  • This list comes from human-food resources. The lists below were compiled by researching several human-food resources for histamine-restricted diets. Then, we screened those lists against the highest recommended foods for dogs with cancer. Why? Because dogs and humans share many similarities physiologically, and dogs are the preferred test subjects for human cancer research. What helps us in our diet usually helps them in their diet when it comes to cancer. Some of these sources are The Histamine and Tyramine Restricted Diet, and The Histamine Restricted Diet.
  • No list will ever be perfect or apply to every dog. This list contains foods that are generally safe and liked by dogs in general. That said, YOUR dog may not like some of these foods. Your dog may not be able to digest some of them well. Every dog is different, and what works for most may not work for your dog, and vice versa.
  • You will find conflicting information online. It would be great if every article you read agreed with every post, comment, or tweet. And it would be really great if every thing you read online agreed with what your veterinarian recommends. Well, that’s not real life. As you research histamine and mast cell tumors, you may find a list that recommends against one or more of the items below. You may find lists that contain other foods. You can find anything on the internet if you try hard enough. We researched low-histamine foods and high-histamine foods and then screened them against the dog cancer diet. These lists are not like other lists.
  • Don’t drive yourself (and your dog) crazy about histamine. Remember that it’s nearly impossible to eliminate everything that may trigger histamine. What we are trying to do here is reduce histamine load by not adding it via the diet. This is better than ignoring the problem, but it’s not addressing every histamine problem. Give yourself a break if your dog is still uncomfortable even if you change the food. Mast cell tumors are not fun.


The Definite ‘No’ List: High Histamine Foods to Avoid

Here is a list of foods or ingredients that should be completely avoided if possible if your dog is in histamine overload. A few of these are included in Dr. Dressler’s dog cancer diet, so I have listed modifications below. Otherwise, avoid:

All Fermented Foods
All Processed Foods
All Leftovers
All Fish**
All Berries***
All Stone Fruits (ex: Apricots)
All Cheese
Citrus Fruits
Yogurt
Tomatoes
Soy
Apples
Quorn
Quinoa
Yeast products like Bread
Cottage Cheese*
Eggs
Walnuts and Pecans
Processed Oils with BHA/BHT
Anything Pickled
Anything with Vinegar

*Cottage cheese is included in Dr. Dressler’s dog cancer diet for its food-based calcium content. And, because dogs love it. If you are avoiding cottage cheese to reduce histamine, make sure you give chicken or turkey necks as outlined in the diet … or give a calcium supplement, or ground-up and boiled eggshells.

**Fish is on the list of proteins you could give in Dr. Dressler’s diet, and he also recommends giving sardines as treats. While your dog is avoiding histamine, do not use fish as your protein, and avoid sardines. (Sorry, puppy, I know they are delicious.)

***Berries that are dark and deeply colored, like raspberries, blueberries, and blackberries, are included in the diet as “optional healthy toppings.” While your dog is in histamine overload, don’t add them.

The Recommended ‘Yes’ List: Low Histamine Foods to Include

I hope you’ll be pleasantly surprised with this list. Most of these foods are already included in the dog cancer diet!

When you are reducing histamine, focus on using the following low-histamine foods:

Chicken Breasts
Lean Beef (trim off any fat)
Turkey Breasts
Chicken or Turkey Necks
Liver
Mung Beans
Organic, Rolled Oats (not instant)
Brown Rice (not instant)
Cooked Cabbage
Broccoli
Brussels Sprouts
Butternut Squash
Cauliflower
Red and Yellow Bell Peppers
Pure Peanut Butter
Fresh Garlic Cloves (in small amounts of course)
Fresh Ginger
Coconut Oil
Krill Oil/Extra Virgin Olive Oil
Flaxseed/Linseed Oil

Now, if you look at that list, you will see about 90% of the foods listed in the dog cancer diet there. So, see? Most of the diet is good for cancer AND low in histamine.

As always, the better quality, organic meats are always better to serve, if possible. And please check out the cooking guidelines below as well.

 

Low Histamine Commercial Dog Food … ???

Unfortunately, even among the best-quality commercial dog foods, we have yet to find one that matches these recommendations.

So if your dog is showing symptoms of histamine overload, cooking for him or her is your best bet.

However, there are some really great foods available these days for when your dog is no longer in histamine overload. We have listed many in the Dog Cancer Shop and Dog Cancer Shop UK.

If a commercial food ever does come on the market that is of high quality and would be appropriate for dogs with histamine overload, we’ll update this article.

Special Cooking Considerations for a Low Histamine Diet

There are a couple of things to keep in mind as you cook for your dog. Histamines can be generated by the cooking process, for example.

Use Low Temperatures, and Don’t OverCook!

Histamine levels rise as meat cooks. And they continue to rise after meat is removed from the heat.

So, always cook your meat at low temperatures (below 300 degrees Fahrenheit).

And don’t overcook your meat.

For example, I’ve found the best way to cook chicken and turkey is to simmer the breasts in a large pot of water.

You get more meat for your money and you have a great broth too. Note: bone broth is high in histamines, but meat broth is not.

Freeze Meat, Don’t Refrigerate It

Histamines can continue to develop in the refrigerator, so refrigerating your cooked meat is not as good as freezing it. (Refrigerating cooked vegetables and grains is less troublesome.)

I freeze cooked meat immediately in meal-sized portions.

And don’t throw out that broth — it can be frozen in ice cube trays for treats. Or, you could use small containers that yield frozen brothcicles to melt down later for your dog’s delight. Freeze in containers up to a cup in size.

No Leftovers for a Low Histamine Diet

Leftovers are on the “no” list above, but it’s worth discussing this a little.

Many of us cook the dog cancer diet in a big batch and refrigerate it for a few days.

But if your dog has mast cell tumors, and you need a low-histamine diet, you might consider freezing every day’s portion individually.

That’s because histamines rise in food as they sit in the fridge.

Leftovers have higher histamines than fresh cooked foods. When you freeze the fresh-cooked food, you avoid excess histamine accumulation.

Again, vegetable and grain leftovers also develop histamines as they sit. But they do it more slowly than meat.

It really depends upon your own kitchen habits, but it may be most convenient to cook a big batch of food and then freeze it in portions. That way you know you are avoiding excess histamines that might develop in the fridge.

Are Fish & Krill Oil Supplements Safe for a Low Histamine Dog Cancer Diet?

If fish is high in histamines, is there cause for concern if you give your dog a fish oil supplement?

Possibly … although the processing of the fish to get its oil alters the original material, and likely removes any problematic metabolites that cause histamine reactions.

If you want to be very safe and make a conservative choice, avoid fish oil if your dog is in histamine overload.

What about krill oil?

In general, Dr. Dressler recommends krill oil over fish oil supplements for many reasons which he explains in the book. We have found that Mercola Krill Oil and Jarrow Formula Krill Oil report that any histamine is “below detectable levels” which is about as good as it can get.

Generally, the benefits of giving a high-quality krill oil for its anti-cancer properties outweigh the infinitesimal amount of histamine which may be present.

Krill oil (and fish oil) are important supplements in full spectrum cancer care. Giving krill oil, especially, is almost certainly better than avoiding it for the infintesimal level of histamines it may contain.

Both of these oils are available through the Dog Cancer Shop.

 

A Labor of Love for Your Dog with Mast Cell Tumors

All of this sounds like a lot of work, I know. But once you’re in the swing you can actually make your doggie food preparation a lot of fun.

When you have your ingredients, a little organization and an hour of time are all you need to prepare a week of food for your dog.

While your meat is cooking you can prepare a pot of organic, rolled oats or brown rice, and lightly cook the vegetables.

Store the meat portions in one container, oat/rice in another, and the various vegetables in a third.

Freeze the meat, refrigerate the others.

When food time nears you can select from each to make a delicious meal. Either thaw to room temperature if you have the time or warm in a microwave. Remember not to overheat.

I’ll bet your dog will be gazing wide-eyed until you put that bowl down.

I hope this helps those of you out there who were shaking your head in frustration. Take a deep breath, sit down with your dog and make that shopping list. You’re doing great!

Happy Tails!

Susan


Leave a Comment





  1. Linda Skerbec on December 22, 2018 at 6:52 am

    Hi Susan,

    We feel overwhelmed because we just found out that or 7 1/2 year old black lab has cancer.

    He had his spleen removed as well as a little bit of his liver – where a small amount of the cancer
    was found.

    Can you tell mw how this diet helped your dogs.

    – and thank you so much,

    Linda

  2. Edith A Little on November 29, 2018 at 7:56 am

    had been using halo dog food and treats, snuggles started throwing up more and more, vet changed her diet to a science diet for sensitive stomachs, this is a grain based and also put her on probiotic, she has some lumps that we have found that was not there before, have an appointment with vet tomorrow, is this a good food for her to be on since she has had mast cell cancer in the past with clear margins?

    • Dog Cancer Vet Team on November 30, 2018 at 7:16 am

      Hello Edith,

      Thanks for writing! We’re not veterinarians here in customer support, so we can’t offer you medical advice. However, we can provide you with information based off Dr. Dressler’s writings 🙂

      In Chapter 8 of the Dog Cancer Survival Guide, Dr. D recommends these high-quality brands– Halo, Solid Gold, Orijen, Honest Kitchen, Blue Buffalo, and Taste of the Wild– as a second only to a home-cooked diet. If you have concerns about the brand that your vet has recommended, ask them about carcinogens, cooking temps, and etc, to make sure it is safe for your dog. Here’s a link to an article that you may find beneficial: https://www.dogcancerblog.com/articles/full-spectrum-cancer-care/dog-cancer-diet/is-your-dogs-food-helping-or-hurting/

      If you are interested in the Dog Cancer Diet that Dr. D recommends, check out Chapter 14 of the Dog Cancer Survival Guide, or get the free Dog Cancer Diet PDF here: https://store.dogcancerblog.com/products/the-dog-cancer-diet

      Because each dog and their health situations are unique, you should consult with your veterinarian if you would like to feed your dog the Dog Cancer Diet. This way, your vet can tailor the diet to suit your dog’s needs, allergies, sensitivities, and so on 🙂

      Consult with your veterinarian as they know your dog the best, and can advise you on a diet that works best for your girl, and her current treatment plan– and don’t be afraid to ask questions! 🙂

      We hope this helps!

  3. D.Denyer on May 16, 2018 at 9:36 am

    I just found out that my 3 yr old vizsla Baxter has mass cell cancer. Iam so upset over this news. I was wanting to know what food or supplements I could give him that would be safe and hopefully help along with the chemo treatments. Right now he eats Nutro grain free.

    • DogCancerBlog on May 17, 2018 at 8:44 am

      Hi D, Thanks for writing and we’re sorry to hear about Baxter! We have all been touched with canine cancer, and we know what you’re going through with your boy. The Dog Cancer Diet recommended by Dr. Dressler encourages healthy cells, discourages cancer growth and consists of feeding your dog a diet that is human-grade and that he will LOVE 😉 If you can’t give your dog a home-cooked diet, there are a few high-quality commercial brands of dog food that we recommend, such as Halo, Solid Gold or Blue Buffalo.

      D, you may find this Supplements for Dogs with Cancer article to be helpful! You should definitely check with your vet on what supplements to use in conjunction with conventional treatments, like chemo, as they know YOU, YOUR dog and his health situation better 🙂
      https://www.dogcancerblog.com/blog/supplements-for-dogs-with-cancer/

  4. Laura Henschel on March 12, 2018 at 4:56 am

    I thought garlic was toxic to dogs?

  5. Elizabeth Maupin on January 15, 2018 at 8:41 am

    Hello: I received a daily meal plan from another source but am now unsure as it includes 1 egg per day, walnuts, and 2 T unsweetened yogurt and/or cottage cheese. Can you tell me why these foods are NOT recommended?

  6. Lia Azevedo on October 22, 2017 at 6:37 am

    Hello everyone,

    I am from Portugal and this type of marvelous aproaches to câncer don’t even exist gere.

    I Have a 5yo French Bulldog That was diagnosed with Insulinoma Stage 3.

    Since the ketogenic diet is low on carbs or with no carbs at all and the Insulinoma causes hypoglicemia what type of ketogenic recipes can I Feed my dog?

    He went trought surgery last week and the Vet took 6 cists and 1 linfonodule, as well as a part of the liver. He is very good and I don’t think is in pain But I would like to try my best to have him with me healthy as long as I can.

    Can you help me please cause I don’t know the quantities I should Feed him since is not a very active dog and he weights around 13,5kg. I have a lol of ebooks about this, the frete ones blecaute I used all my money and my credit card is out but I am still afraid am I not giving him the right quantities of food. I am giving him around 140gr of cooked cow meet and 7gr of brócolos and One small spoon of coconut oil, 2 Times a day.

    HELP ME PLEASE, I AM DESPERATE, he is my everything.

    Kind regards

  7. FD on May 29, 2017 at 7:58 pm

    Hi Susan, I hope that you are still monitoring this post. Just wanted to let you know that this article is was so informative. The items on the suggested, “Yes” list are very similar to the foods I eat daily, so it’ll be easy for me to prepare healthy meals for my pup. Although my dog does not have cancer, I believe preventive health care is just as important. Thanks again for sharing this post!

  8. Cindy Bueso on June 13, 2016 at 10:32 am

    Hello, my dog was diagnosed with mast cell tumor and she just started taking Avemar which is fermented wheat germ but reading your blog I found out that releases more histamine… what should I do?

  9. Susan Kazara Harper on June 23, 2015 at 7:46 pm

    What wonderful news. Well done, John! Prognosis are always based on the statistics at hand, and can’t possibly take into account the spirit of the dog or all the love, care and support from their best human friends. Give your girl a wonderful hug form us. !!!

  10. John Thompson on June 20, 2015 at 2:24 am

    My dog has lung cancer. I have been making this for my dog.

    kidney beans
    garbanzo beans
    black turtle beans
    broccoli
    carrots
    beats
    kale

    cook in crock pot and use food processor to make paste
    server one scoop with these on the top
    olive oil
    cod liver oil
    shiitake mushroom
    salmon
    1/4 cube of unsalted butter

    also
    green tea extract
    a drop Indica with high thc
    milk thistle

    She has been alive now for almost a year. The vet gave her two weeks.

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