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	<title>Comments on: When to Avoid Chemo for Canine Mast Cell Tumors?</title>
	<atom:link href="http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/feed/" rel="self" type="application/rss+xml" />
	<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/</link>
	<description>Dr. Demian Dressler, DVM, the dog cancer vet blogs about canine cancer</description>
	<lastBuildDate>Thu, 11 Mar 2010 21:09:39 +0000</lastBuildDate>
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		<title>By: Dr. Dressler</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2531</link>
		<dc:creator>Dr. Dressler</dc:creator>
		<pubDate>Tue, 09 Mar 2010 02:32:26 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2531</guid>
		<description>Dear Todd, 
the Grade of the mast cell tumor is the first thing that predicts behavior.  Mitotic index is a second level predictor once the grade is established and is most useful for Grade 2 (intermediate grade) mast cell tumors where you don&#039;t know if it will behave aggressively or not.  Then we look at mitotic index and some other things to try to predict behavior.
I hope this helps
Dr D</description>
		<content:encoded><![CDATA[<p>Dear Todd,<br />
the Grade of the mast cell tumor is the first thing that predicts behavior.  Mitotic index is a second level predictor once the grade is established and is most useful for Grade 2 (intermediate grade) mast cell tumors where you don&#8217;t know if it will behave aggressively or not.  Then we look at mitotic index and some other things to try to predict behavior.<br />
I hope this helps<br />
Dr D</p>
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		<title>By: Dr. Dressler</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2519</link>
		<dc:creator>Dr. Dressler</dc:creator>
		<pubDate>Tue, 09 Mar 2010 00:31:02 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2519</guid>
		<description>Dear Russ,
I am sure the decision not to pursue surgical removal has been thoroughly discussed? The vast majority of Grad 2 mast cell tumors can be removed with a wide excision surgery (yes, even old dogs) as long as it has not spread already.
You need to decide what your priorities are by defining your own values.  Life quality or life quantity?  This is discussed in detail in the &lt;a href=&quot;http://www.dogcancersurvival.com&quot; rel=&quot;nofollow&quot;&gt;Guide&lt;/a&gt;.  In the realm of conventional cancer care, if life quantity goes up, life quality risks go up too.  I assume you have information about diet? 
http://www.dogcancerblog.com/diet-for-dogs-with-mast-cell-tumors/
Also you want to stabilize any mast cells in the body and deal with histamine:
http://www.dogcancerblog.com/mast-cells-and-luteolin-in-cancer-treatment-part-1/
of course I am partial to the &lt;a href=&quot;http://apocaps.com/home/&quot; rel=&quot;nofollow&quot;&gt;supplement that I use in my patients&lt;/a&gt; that contains luteolin :)
You need this info:
http://www.dogcancerblog.com/dog-cancer-decisions-in-the-gray-zone/
and
http://www.dogcancerblog.com/mast-cell-tumors-in-dogs-some-advances-in-conventional-care/
also you may want to have your vet call Dr. Ahn at AB sciences in New Jersey to access masitinib, a pre-FDA approval drug that may help.
Best,
DR D</description>
		<content:encoded><![CDATA[<p>Dear Russ,<br />
I am sure the decision not to pursue surgical removal has been thoroughly discussed? The vast majority of Grad 2 mast cell tumors can be removed with a wide excision surgery (yes, even old dogs) as long as it has not spread already.<br />
You need to decide what your priorities are by defining your own values.  Life quality or life quantity?  This is discussed in detail in the <a href="http://www.dogcancersurvival.com" rel="nofollow">Guide</a>.  In the realm of conventional cancer care, if life quantity goes up, life quality risks go up too.  I assume you have information about diet?<br />
<a href="http://www.dogcancerblog.com/diet-for-dogs-with-mast-cell-tumors/" rel="nofollow">http://www.dogcancerblog.com/diet-for-dogs-with-mast-cell-tumors/</a><br />
Also you want to stabilize any mast cells in the body and deal with histamine:<br />
<a href="http://www.dogcancerblog.com/mast-cells-and-luteolin-in-cancer-treatment-part-1/" rel="nofollow">http://www.dogcancerblog.com/mast-cells-and-luteolin-in-cancer-treatment-part-1/</a><br />
of course I am partial to the <a href="http://apocaps.com/home/" rel="nofollow">supplement that I use in my patients</a> that contains luteolin <img src='http://www.dogcancerblog.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' /><br />
You need this info:<br />
<a href="http://www.dogcancerblog.com/dog-cancer-decisions-in-the-gray-zone/" rel="nofollow">http://www.dogcancerblog.com/dog-cancer-decisions-in-the-gray-zone/</a><br />
and<br />
<a href="http://www.dogcancerblog.com/mast-cell-tumors-in-dogs-some-advances-in-conventional-care/" rel="nofollow">http://www.dogcancerblog.com/mast-cell-tumors-in-dogs-some-advances-in-conventional-care/</a><br />
also you may want to have your vet call Dr. Ahn at AB sciences in New Jersey to access masitinib, a pre-FDA approval drug that may help.<br />
Best,<br />
DR D</p>
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		<title>By: Russ</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2504</link>
		<dc:creator>Russ</dc:creator>
		<pubDate>Mon, 08 Mar 2010 17:52:14 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2504</guid>
		<description>Oops! I should have said -- over 50 tumors removed since September of 2005.

Thanks</description>
		<content:encoded><![CDATA[<p>Oops! I should have said &#8212; over 50 tumors removed since September of 2005.</p>
<p>Thanks</p>
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		<title>By: Russ</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2495</link>
		<dc:creator>Russ</dc:creator>
		<pubDate>Sat, 06 Mar 2010 03:54:51 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2495</guid>
		<description>Dear Dr. Dressler

Lola, my four-legged companion has had over 50 tumors removed since September of last year.   Lola has been with me for nine years at the end of April.  I assume Lola to be at least eleven or twelve years of age since she was a stray.

When I brought Lola into my home, she had two bumps on her.  The dermatology vet hospital where I took Lola, told me to ignore the bumps because the bumps were nothing more than fat tumors.  The dermatology clinic owners have a monopoly of dermatologists in southern California, Hawaii and other locations.  So, getting a second opinion is impossible.  Instead they put Lola through all kinds of allergy tests because she had terrible allergy problems.  Not once did they mention the use of Benadryl.  

Three and half years later, one of the two bumps changed colors.  I knew something wasn’t right.  I took her to a vet hospital to it aspirated.  The bump Came back positive and the two tumors plus a third were removed.  All grade 2, level 1.  Had the dermatology clinic performed their job as they should have, I would’ve taken a complete different path for Lola’s health. 

First of all, I wouldn’t have allowed all those various vaccines to be given to her.  It wasn’t until after the fact that I learned all those vaccines are not good because of the potential diseases they can produce.  I would’ve taken a more holistic approach to her diet as I now do, and eliminated many of the drugs I believe have caused her immune system to be challenged.

Recently, six active tumors were injected with a very small dose of steroid.  Since Lola’s system is very sensitive, the oncologist said the amount given is far below what is normal for a dog her size and weight.  Lola does react well to the small dosages.

Now I am at a cross roads of what to do.  The oncologist suggested a chemo drug (the generic version) as a pill to give her.  I’ve resisted this because I am frightened by the potential side affects.  What do you think?

Sincerely,
Russ</description>
		<content:encoded><![CDATA[<p>Dear Dr. Dressler</p>
<p>Lola, my four-legged companion has had over 50 tumors removed since September of last year.   Lola has been with me for nine years at the end of April.  I assume Lola to be at least eleven or twelve years of age since she was a stray.</p>
<p>When I brought Lola into my home, she had two bumps on her.  The dermatology vet hospital where I took Lola, told me to ignore the bumps because the bumps were nothing more than fat tumors.  The dermatology clinic owners have a monopoly of dermatologists in southern California, Hawaii and other locations.  So, getting a second opinion is impossible.  Instead they put Lola through all kinds of allergy tests because she had terrible allergy problems.  Not once did they mention the use of Benadryl.  </p>
<p>Three and half years later, one of the two bumps changed colors.  I knew something wasn’t right.  I took her to a vet hospital to it aspirated.  The bump Came back positive and the two tumors plus a third were removed.  All grade 2, level 1.  Had the dermatology clinic performed their job as they should have, I would’ve taken a complete different path for Lola’s health. </p>
<p>First of all, I wouldn’t have allowed all those various vaccines to be given to her.  It wasn’t until after the fact that I learned all those vaccines are not good because of the potential diseases they can produce.  I would’ve taken a more holistic approach to her diet as I now do, and eliminated many of the drugs I believe have caused her immune system to be challenged.</p>
<p>Recently, six active tumors were injected with a very small dose of steroid.  Since Lola’s system is very sensitive, the oncologist said the amount given is far below what is normal for a dog her size and weight.  Lola does react well to the small dosages.</p>
<p>Now I am at a cross roads of what to do.  The oncologist suggested a chemo drug (the generic version) as a pill to give her.  I’ve resisted this because I am frightened by the potential side affects.  What do you think?</p>
<p>Sincerely,<br />
Russ</p>
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		<title>By: Todd Gilman</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2489</link>
		<dc:creator>Todd Gilman</dc:creator>
		<pubDate>Fri, 05 Mar 2010 17:24:42 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2489</guid>
		<description>Hi Dr. D,

I just read this article and was hoping you could comment.  My dog&#039;s mast cell tumor had a mitotic rate of 0-1 when staged back in Sept.  It was excised, with narrow margins the first time and came back in 2 weeks, so the vet did it again and got wide margins, again with 0-1 MR.  The tumor came back again and we were referred to www.fvs.com  They have given him every chemo drug in the book(vinblastine, palladia, lumostine) and he has not responded at all.  His lymph node was the size of a tennis ball.  The oncologist gave us a drug from Europe(I don&#039;t remember the name).  It shrunk the lymph node by half but that was all.  

I was hoping you could comment on how this tumor is so aggressive with a mitotic rate of 0-1.  Nothing we do works. Also, if you have any advice on any other options, it would be greatly appreciated.  For your info, Kramer is a 11 y.o. Weim/Greyhound mix.

BTW, Got the book and thought it is very well done. 

Thank you very much for your time.</description>
		<content:encoded><![CDATA[<p>Hi Dr. D,</p>
<p>I just read this article and was hoping you could comment.  My dog&#8217;s mast cell tumor had a mitotic rate of 0-1 when staged back in Sept.  It was excised, with narrow margins the first time and came back in 2 weeks, so the vet did it again and got wide margins, again with 0-1 MR.  The tumor came back again and we were referred to <a href="http://www.fvs.com" rel="nofollow">http://www.fvs.com</a>  They have given him every chemo drug in the book(vinblastine, palladia, lumostine) and he has not responded at all.  His lymph node was the size of a tennis ball.  The oncologist gave us a drug from Europe(I don&#8217;t remember the name).  It shrunk the lymph node by half but that was all.  </p>
<p>I was hoping you could comment on how this tumor is so aggressive with a mitotic rate of 0-1.  Nothing we do works. Also, if you have any advice on any other options, it would be greatly appreciated.  For your info, Kramer is a 11 y.o. Weim/Greyhound mix.</p>
<p>BTW, Got the book and thought it is very well done. </p>
<p>Thank you very much for your time.</p>
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		<title>By: mike</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2288</link>
		<dc:creator>mike</dc:creator>
		<pubDate>Mon, 01 Feb 2010 03:00:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2288</guid>
		<description>fyi..i just purchase paladia from my vet for $220 for 30 pills for my schnauzer</description>
		<content:encoded><![CDATA[<p>fyi..i just purchase paladia from my vet for $220 for 30 pills for my schnauzer</p>
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		<title>By: Jonny White</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2194</link>
		<dc:creator>Jonny White</dc:creator>
		<pubDate>Mon, 18 Jan 2010 20:52:54 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2194</guid>
		<description>Dr. D,

Our 5yr old Great Dane/Lab mix recently had a tumor roughly the size of a walnut removed from the back of her leg. The pathology came back as Grade I mast cell tumor, with a mitotic index of 0-1. However she has 3 other smaller growths the size of a pea in other surgically aceptable areas. 

My question is are we likely to have ongoing tumors appear and what is the prognosis if we continue to see new tumors. Can we expect to have all of these sucessfully removed thru surgury given her pathology or is her outlook likely to deteriorate over time. 

My vet seams optomistic but we don&#039;t want to be caught of guard given this may not be the only malignant tumor.</description>
		<content:encoded><![CDATA[<p>Dr. D,</p>
<p>Our 5yr old Great Dane/Lab mix recently had a tumor roughly the size of a walnut removed from the back of her leg. The pathology came back as Grade I mast cell tumor, with a mitotic index of 0-1. However she has 3 other smaller growths the size of a pea in other surgically aceptable areas. </p>
<p>My question is are we likely to have ongoing tumors appear and what is the prognosis if we continue to see new tumors. Can we expect to have all of these sucessfully removed thru surgury given her pathology or is her outlook likely to deteriorate over time. </p>
<p>My vet seams optomistic but we don&#8217;t want to be caught of guard given this may not be the only malignant tumor.</p>
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		<title>By: Dr. Dressler</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2143</link>
		<dc:creator>Dr. Dressler</dc:creator>
		<pubDate>Sat, 09 Jan 2010 17:47:41 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2143</guid>
		<description>Dear Gary, 
you need to understand this is a very serious cancer.  The statistics are rather dreadful: less than 2 month survival time for a grade 3 mast cell tumor with a mitotic index of greater than 5. I would consider the whole arsenal in a 7 year old Eglish Bulldog, depending on what type of person you are (how risk averse).  I would utilize the full range of surgery, chemo, possibly radiation (the latter two under oncologist supervision), as well diet, supplements, life quality measures etc. that I describe in the Dog Cancer Survival Guide.  You should also pay close attention to the treatment plan analysis portion of the book due to the grim numbers involved in cases like your dog&#039;s, to make sure that what you do makes sense to you and feels right from an ethical standpoint.
Dr D</description>
		<content:encoded><![CDATA[<p>Dear Gary,<br />
you need to understand this is a very serious cancer.  The statistics are rather dreadful: less than 2 month survival time for a grade 3 mast cell tumor with a mitotic index of greater than 5. I would consider the whole arsenal in a 7 year old Eglish Bulldog, depending on what type of person you are (how risk averse).  I would utilize the full range of surgery, chemo, possibly radiation (the latter two under oncologist supervision), as well diet, supplements, life quality measures etc. that I describe in the Dog Cancer Survival Guide.  You should also pay close attention to the treatment plan analysis portion of the book due to the grim numbers involved in cases like your dog&#8217;s, to make sure that what you do makes sense to you and feels right from an ethical standpoint.<br />
Dr D</p>
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		<title>By: Gary</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2123</link>
		<dc:creator>Gary</dc:creator>
		<pubDate>Mon, 04 Jan 2010 04:28:05 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2123</guid>
		<description>Dr. Dressler, I just found out that my English Bulldog, 7 years old, has a poorly differentiated Grade III mast cell tumor.  The biopsy report said the &quot;mast cell tumor appears completely excised.&quot;  However, it says her mitotic index is 6/10.  How bad is that number?  Thank you very much.

Gary</description>
		<content:encoded><![CDATA[<p>Dr. Dressler, I just found out that my English Bulldog, 7 years old, has a poorly differentiated Grade III mast cell tumor.  The biopsy report said the &#8220;mast cell tumor appears completely excised.&#8221;  However, it says her mitotic index is 6/10.  How bad is that number?  Thank you very much.</p>
<p>Gary</p>
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		<title>By: hitaloyappy</title>
		<link>http://www.dogcancerblog.com/when-to-avoid-chemo-for-canine-mast-cell-tumors/comment-page-1/#comment-2095</link>
		<dc:creator>hitaloyappy</dc:creator>
		<pubDate>Wed, 30 Dec 2009 06:38:18 +0000</pubDate>
		<guid isPermaLink="false">http://www.dogcancerblog.com/?p=1151#comment-2095</guid>
		<description>Thanks for the informative information - I enjoyed reading it! I always enjoy this blog. :) Cheers, &lt;a href=&quot;http://live-birth-video.com&quot; rel=&quot;nofollow&quot;&gt;live-birth-video.com&lt;/a&gt;</description>
		<content:encoded><![CDATA[<p>Thanks for the informative information &#8211; I enjoyed reading it! I always enjoy this blog. <img src='http://www.dogcancerblog.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' />  Cheers, <a href="http://live-birth-video.com" rel="nofollow">live-birth-video.com</a></p>
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