Dog Cancer Survival Video
Name:
Email:
Jan
25

Dog Cancer and the Malaria Drug Artemisinin, Part 2

By Dr. Dressler

This is a continuation post on artemisinin, a compound that is found sweet wormwood. This agent is currently used for malaria treatment. Recently there has been interest in it’s application in dog cancer treatment. It has caught on in bone cancer care for dogs (osteosarcoma).

In the last post we summarized some mechanisms where artemisinin may help with several different cancer types. There are certainly in vitro (test tube) studies that show artemisinin, or closely related agents, can kill cancer cells.

Unfortunately killing a cancer cell in a petri dish may have nothing to do, whatsoever, with killing cancer in a living body. Hundreds upon hundreds of compounds show promise in the test tube and when used in a lab animal, dog or human do very little to nothing.

Is there evidence that arteminisin, or analogs (an analog is a related compound), work in living bodies?

Well, there is a case report in print out of India where the artemisinin analog artesunate was used to treat a human patient with laryngeal cancer with good results. However, injections were given, in addition to tablets. Dog lovers would need to go to their veterinarians regularly to accomplish this. Click here for the link.

The journal Clinical Cancer Research recently published an article (here is is) that showed that artemisinin was capable of slowing the growth of hepatoma (liver) cancer cells in mice.

There was another article (here you go) that showed some semi-synthetic derivatives of artemisinin helped a mouse model of prostate cancer too.

Finally, kidney cancer cells put in mice showed slowed growth and angiogenesis (new blood vessel formation to feed the cancers) when the mice were treated with the artemisinin analog artesunate. Here is the abstract.

So there’s some evidence that something or other is indeed going on here.

A new drug is being made by Dr. Lai, one of the original artemisinin guys in cancer treatment at the University of Washinton. The drug improves it’s cancer killing effects by boosting its movement into cancer cells with iron. (See the last artemisinin post for more on the iron topic).

My overall impression here is that we are pretty early in the game to say we have a real contender. Not that we do not have a real contender, just that it seems the hype may not be in proportion to the documented effects. Investigation and consideration is strongly advised!

If you want to investigate and consider artemisinin with your vet or oncologist, the possible dose spread is huge, vaguely around 2 to 15 mg per pound one time a day. There is much variation on recommended doses.

Here is some other info on artemisinin:

Give with some oily material (omega 3 fatty acids would be one option).
Give 1 week on, 1 week off, since the absorption if artemisinin decreases after about 1 week.
Do not use if your dog is on seizure control medication.
Do not use when your dog is getting radiation.
Possibly can be used with most chemo agents, but all interactions have not been assessed.
Antixodant effects may interfere with artmesinin’s activity.
Upset stomach may be seen with artemisinin. Rare liver marker elevation and suppression of blood cells has been seen in humans. Here is a safety review in humans.
Do not give artemisinin with iron in the food or it can react with this iron and be consumed before it enters cancer cells. Meat, fortified foods, and supplements are some common iron sources in the diet.

Best to all,

Dr Dressler

About the Author


Demian Dressler dog cancer veterinarianDr. Demian Dressler, DVM is known as the "dog cancer vet" and is author of Dog Cancer Survival Guide: Beyond Surgery, Chemotherapy & Radiation. Visit his blog and sign up free to get the latest information about canine cancer. Go to http://DogCancerBlog.com.

 

Share and Enjoy:
  • Digg
  • del.icio.us
  • Facebook
  • Mixx
  • NewsVine
  • Reddit
  • StumbleUpon
  • YahooMyWeb
  • Google Bookmarks
  • MySpace
Categories : Main Content

Dog Cancer

14 Comments

1

Dear Dr. Dressler,
Thank you for this site; it is comforting to me at this difficult time.

I am torn whether to ampute my dog’s left, front arm and shoulder now or proceed with aggressive Radiation therapy first.

He has aggressive Liposarcoma, low grade, low stage (I asked and these were the terms given). I’ve had to be assertive in inquiry and advocacy to get him into the veterinary oncologists by referral within 2 weeks of the tumor appearing. Thanks to your blog and other web research, I managed it and am grateful I had the courage and fortitude to push through thus far. His CT shows no metastasis beyond his limb at this point.

The tumor arrived Jan. 1, 2009. Today, Jan. 28, 2009 the veterinary surgical oncologist went back in and removed all she could that remained of the cancer. She said without amputation she could not get it all, however. The pathologist from his first biopsy (which went slightly awry because the tumor ‘popped’ out during the procedure unexpectedly, yielding more than the intended circumference of removal than anticipated) indicated unclear margins).

We now await the pathologist’s report from this second surgery, although with the surgeon’s assessment that more cells remain behind without amputation.

I’ve read and carefully considered your posts re. Radiation Therapy and how serious it is and done the life expectancy estimation for my dear dog Milo. He is 10 now, a small terrier, min-pin mix, with an optimistic life expectancy of 15 years had cancer not visited.

Per your recommendation, I am considering the alternatives and options available to me. Both the veterinary surgeon and veterinary oncologist recommend the aggressive, 19 consecutive day Radiation therapy to target the remaining cancer cells. This seems very aggressive to me and I worry for the aftermath of toxic effects and latent consequences of the Radiation for the remainder of his next 5 years should we succeed in a cure.

Per your formula, he is NOT at the end of his life expectancy yet; he has at least 5 years left God willing.

My question is if I should be proactive and choose amputation with radiation (although the surgeon said that with amputation no radiation is necessary although what I’ve read says radiation is still advised…??? Is it?) or…

If I should subject him to this massive amount of radiation for 19 consecutive days and amputate only if/when another tumor/bump/lump appears later on?

Is there an option for amputation now with a lower dosage of radiation?

Is the risk of toxic, latent, residual effects from intense, heavy, radiation over the next 5 years a better bet than amputation now, while the cancer is still contained within the limb, plus a lesser amount of radiation as a ‘just in case’ treatment???

I want him to feel the least amount of ’sick’ and ’scared’ for the remainder of his days with the best quality of life and be cancer-free or at least cancer-clueless if possible!

He’s one of those dogs that just WANTS to run and fetch the tennis ball and play tuggie and look at the window and meet other dogs! Milo’s got that joie de vive in buckets, Dr. Dressler! He fits into that ‘type’ of dog you described when trying to make this choice in your post.

So I know he’d bounce back from amputation sooner than later! He’s a super trooper!

And I realize that cancer may reappear somewhere else later, maybe sooner, and then he’d still be one leg shy of a set.

Like the celebrity Christina Applegate who opted for a double masectomy after being tested and due to her familial breast cancer history of onset, I’m willing to be proactive and opt for amputation now because:

1) Both the original pathologist and today’s vet. onco. surgeon admit the cancer cells are still there in the back of his upper arm and due to the location, clean margins of removal cannot be obtained without amputation.

But I don’t want to take his leg off unnecessarily or prematurely either if radiation therapy could work withOUT resulting in likely toxic effects within the next 5 years of his expected life span.

I can’t seem to get a feel for the REAL fall out effect of such aggressive and intense radiation therapy on a little 18 lb. love of my heart dog! ‘They tolerate it so well’ is all I could get from the veterinary oncologist (probably because I wasn’t asking the correct questions I know!) But I’ve bought your book and will work to improve my game. ;-)

Radiation is gross. We all know it. I don’t want to radiate my dog if it means that 2 of his 5 years will be spent dealing with likely toxic effects of it in the form of new tumors FROM the radiation and plethora other fallout.

If amputation means ‘a stitch in time…’ or ‘a bird in hand…’ plus either no radiation or lesser radiation will more likely yield Milo 5 FUN, healthy, happy years with less radioactive fallout on his body, then I’m willing to do that.

What do you think? HELP! I’m on information overload.

I just bought your book and will begin the ‘coping’ exercises asap.

Milo’s spending the night at the oncology center tonight, my sweet little man. My love. My heart. I don’t know what to do!

Thank you and God Bless You, Dr. Dressler,

Please let me know…

Sincerely,

Lorene Moore aka Milo’s Mom

2

Lorene,
this is a yucky one. However, I believe I will help you by acknowledging that you have already answered your own question. I always say this, but I cannot give advice on individual dogs in this blog. Go with your gut on this one. You know what I am saying. My opinion only.
Also, get the next book when it comes. The supplement sections on curcumin/luteolin may help your little Milo.
Give Milo a hug for me,
D

3

Hi Dr Dressler,
My Boxer Brandi has been dianosed with Canine cutaneous epitheliotropic T cell lymphoma(mycosis fungoides)in her mouth. Our vet told me this cancer doesn’t respond to chemo. I know this well as they did try chemo on Brandi’s brother for the same disease in 2005. It was not in his mouth but all over his body and the chemo did not work.
I was told Brandi’s is not as aggressive and to treat palliative, I take this as give up.
At once I started to do reseach on alternative treatments.
I ordered artemisinin and started her on 100mg 2x a day. Then I found your book, I ordered both the ebook and hard book.
Since being off the Arte on the 5 on 5 off schedule I have been alternating it with parsley and I have also bought curcuin but not used it yet.
I am going to be starting the arte again soon and would like to go with the 10mg/lb/day dose as per your book.

My question is do I give it 2 times a day or only once. She is 64.4 pound and 10 years old
So that would be 640mg of Artemin once or 320mg twice a day? I would have to measure out a half a capsule to get the 40mg as I only have 100mg capsules.
Also would the Luteolin be a better rotation supplement, she really doesn’t like the parsley and has been not eating all her dinner since using it.
also any ideas on what I could use on her mouth for the inflammation, it looks so sore.
Thank you
Peg & Brandi

4

Peg and Brandi,
print this abstract out and take it to your vet. See the blog posts on CLA too…
http://www.ncbi.nlm.nih.gov/pubmed/1596872
There is no evdience to say that the Arte is better or worse once or twice daily. Give the total amount in a 24 hour period, other than that it is your call. You can round up on the Art dose to fit the capsule sizel….whatever is easiest. Please be in touch with your vet about everything you are doing!
Good luck!!
D

5

Hi Dr Dressler,
Thank you so much for getting back to me. I am very happy with your book just get a little confused about some of the things.

I printed the info you gave me and will be taking it to the vet.
I have been keeping them informed of everything I am doing for Brandi. I told them if they are not giving me any options on treatments I will do what I have to to help her.

They are not happy with the use of Arte and won’t even talk about the dosage, however they are willing to run periodic blood work and checks on her to check for any other problems associated with it or any other supplement I use. To my surprise, they did prescribe Doxycycline when I ask and agreed with it. With that, I guess they ARE willing to work along with,m e but not comfortable with prescribing some herbal treatments.
They have even told me I am wasting my money using transfer factor and K9 immunity. I ask what they would give her for support and they said nothing.
They also are not happy with the cancer diet for Brandi, they feel that with a dog her age(10) it would be too much for her kidneys. As of now Brandi has no problems associated with kidney problems so I am not sure if they are right.
I should have ask you that question too. What would be the right diet for her given her age and lymphoma? Your cancer diet or the ND version?
Thank you again,
Peg & Brandi

6

Peggy,
high protein diet does not cause kidney disease. It should not be used though if the kidneys are diseased already though…
Having said that, Greg Oglivie, arguably the most prominent veterinary oncologist in the country, designed ND. So in the conventional realm, he is a top dog. No offense to any other vet out there, but…you get the idea.
Why don’t you use both of the diets…use some ND and some of the home diet??
Can’t say what is better, no data, but this is a nice approach.
I will address your question in more detail in the upcoming webinar:
http://dogcancervet.com
best,
D

7

There is a list of artemisinin-cancer related publications in:
http://depts.washington.edu/bioe/artemisinin.html

8

Thank you Dr. Lai!
D

9
Judith Conigliaro
June 19th, 2009 at 6:16 am

My Westie Abby who has bladder cancer was on Artemisinin and at first, the tumor shrank. However, due to constant vomiting, we opted to forego this treatment. Is there something perhaps I could give Abby to contradict the stomach upset in order to continue with Artemisinin. Also, I do feed Abby chicken. Could this iron source have been the reason for the stomach upset? What type of food do you recommend when administering Artemisinin?

I thank you for any response you can give.

Judi Conigliaro
gee_a_puppy@yahoo.com

10

Judith, consider cimetidine (tagamet) for the stomach upset. I doubt the iron in the chicken is causing the stomach upset, more likely the artemisinin or something else being given by mouth.
I will discuss your question more fully in this weeks webinar:
http://mydogvet.com
Thanks for the question!
Dr D

11

FYI the webinar is recorded so you can listen later if you wish,
D

12

My dog, a female 12 year old boxer (3/4) has hemangiosarcoma, she weighs about 60 lbs. I have seen different recommended doses for ART ranging from 100 to 600 MG, what do you recommend. Also, she is taking an iron supplement- how long should I wait after giving this to begin giving the treatment or is it just a concern while in the stomach/

13

My dog, Nick is a 10 year old Akita with osteosarcoma. He had radiation treatment, ending 3 weeks ago. I want to put him on Artemisinin, but am getting conflicting info on how soon I can sart him. My vet says she’s found nothing about waiting after radiation and I can start him right away, various articles on the web say I need to wait 2 months. What is the earliest I can get him started?

14

Dear Sandra,
the objective data just isn’t there comparing radiation with art to radiation without art. We can only theorize until the studies are done. From a theoretical standpoint, the mechanism by which art works would complement radiation, not interfere with it….but nobody can say whether this holds in real life.
Best,
Dr D

Leave a Comment