Mast Cells and Luteolin in Cancer Treatment, Part 1 - Dog Cancer Blog

Featuring Demian Dressler, DVM and Susan Ettinger, DVM, Dip. ACVIM (Oncology), authors of The Dog Cancer Survival Guide.

≡ Menu

Mast Cells and Luteolin in Cancer Treatment, Part 1

Here’s a post I have been promising for a while now.  Let’s look at Luteolin, a practically anonymous, food-derived agent with numerous possible uses in cancer treatment.

Nobody has heard of Luteolin.  That is because the research being done in its potential anti-cancer application is really new.

What is it anyway? Luteolin is a bioflavonoid that is found in artichokes, peanut hulls, green pepper, chrysanthemums, citrus, and many other natural plant sources.

Here is one of the cool things Luteolin is capable of: mast cell stabilization.

Whoa…   mast cells?  Some dog lovers have heard of mast cell tumors, or may even be dealing with this diagnosis in their loved canine companion.   Mast cells, when doing normal things, secrete chemical signals that are involved in some kinds of inflammation.

Inflammation is a normal part of the body’s defense system. However, like most things in excess, more is not better.

When mast cells in the body secrete too much of their chemical signals, the outcome is redness, swelling, itching and burning.  You get allergic reactions, excessive stomach acid secretion, dilated blood vessels, elevated heart rate, shock, and sometimes even death.

In dog cancer care, we deal with tumors made out of cancerous mast cells. These cells maintain their ability to send out these noxious chemical signals.  Dogs with severe mast cell tumor burdens have things like excessive stomach acid, inflammation in the skin, and physical discomfort due to the nastiness of the excessive histamine, heparin, and substance P released by mast cells.

Here comes the good stuff: Luteolin, very potently, is capable of suppressing the release of these chemicals.  Read more here and here.

But why not just give Benadryl or cimetidine to block these effects? Why not reach for these common meds without pause?

Well, luteolin has some very nice anti-inflammatory effects, and some good potential anticancer effects, which we will go into in next time…so stay tuned…..


Dr Dressler

About the Author: Demian Dressler, DVM

Dr. Demian Dressler, DVM is known as the "dog cancer vet" and is author of The Dog Cancer Survival Guide: Full Spectrum Treatments to Optimize Your Dog's Life Quality and Longevity.

  • James

    This is a very interesting article. Keep it up. I love reading your blog.

    • Joanne

      Dear Dr. Dressler,
      I have a german shepherd/border collie mix (Cassie). She has been diagnosed with a mast cell tumor on her back leg near where the hock and thigh meet. It is inoperable because the vet cannot get the margins and she will be greatly disfigured. Also we did X-rays and two spots showed up – one on bottom of spleen and one somewhere near the lymph node near her lungs. I am going to have an aspirate done of the one on the spleen.
      As removal is not possible what protocol would you suggest for my dog. The vets that I go to are great but they don’t seem to know too much. Suggested amputation which is out of the question. My dog is seven years old and not in any pain that we can see. Weight is stable, appetite good, personality still the same. I know that this is not indication of her health but I do need help in deciding what steps to take. When she is in pain we will then have to think about putting her down but for now we would at least like to try and stabilize her. Thank you for your time.

      • Dr. Dressler

        Joanne, see my other comment, thanks!

    • Dr. Dressler

      why thank you!

  • Dr. Dressler,

    My little 10 year old dog has a mast cell tumour, it swells up hours after she eats any form of protein, why is that? It’s very frustrating as I want the swelling to go down, so I can use black salve, but am scared of all the histiame she may lose when the black salve penetrates the skin. She needs protein but am cornered what can you suggest??? I was also thinking of giving her black salve capsule just a lentil dosage in a capsule, one per day and there is also a tonic111 to give.

    Any thoughts?

    Thanks so much for all you help.


  • moonlightshines

    Its worth taking salvestrols for dog cancer because this is high in Luteolin

  • Pingback: Dr. Dressler's Dog Cancer Kit Features Help, Hope, Answers » Tripawds Downloads » Download Three Legged Dog Cancer Amputation Help Info Resources()